Sorbitol dehydrogenase has been used in a study to investigate osmotic stress induced oxidative damage as a possible mechanism of cataract formation in diabetes.
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|Alternate Names||L-Iditol dehydrogenase; Polyol dehydrogenase; L-Iditol: NAD+ 5-oxidoreductase; EC 18.104.22.168; SDH|
|Application Notes||Sorbitol dehydrogenase has been used in a study to investigate osmotic stress induced oxidative damage as a possible mechanism of cataract formation in diabetes.|
|Base Catalog Number||15664205|
|Biochemical Physiological Actions||Activity of sorbitol dehydrogenase increases in diabetic animals.|
|Pack Size||5 mg|
|Personal Protective Equipment||Eyeshields, Gloves, respirator filter|
|Specific Activity||≥20 u/mg protein|
|Specificity||Reduces L-iditol to L-sorbose. Also acts on D-glucitol and other closely related sugar alcohols. Allows the reduction of ketones to polyols. The reduction of D-fructose is favored. However; alkaline pH shifts the equilibrium in favor of sorbitol oxidation. SDH does not oxidize erythritol; D- or L-arabitol; D-iditol; D-mannitol or inositol. It will not reduce D-tagatose; D-mannoheptulose; D-glucose; DL-glyceraldehyde; pyruvate; 2-oxolutarate or acetaldehyde.|
|Unit Definition||One unit will convert 1.0 umole of D-fructose to D-sorbitol per minute at pH 7.6 at 25 °C.|