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Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole.
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|Alternate Names||1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole; 1-(o-Chloro-α,α-diphenylbenzyl)imidazole; diphenyl-(2-chlorophenyl)-1-imidazolylmethane|
|Application Notes||Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole.|
|Base Catalog Number||19894480|
|Biochemical Physiological Actions||Mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.|
|Molecular Weight||344.842 g/mol|
|Pack Size||100 g|
|Personal Protective Equipment||Dust mask, Eyeshields, Gloves|
|Typical Working Concentration||A concentration of 3μg/mL of clotrimazole is generally effective for inhibiting many fungal species that are sensitive to clotrimazole.|
|UV Visible Absorbance||λmax: 261 nm (Lit.)|