Bafilomycin A1

Application Notes

Bafilomycin A1 is active against gram-positive bacteria and fungi. It is a highly specific inhibitor of vacuolar type H+-ATPase (V-ATPase) in animal cells, plant cells and microorganisms, being effective at nanomolar concentrations in vitro. It inhibits neither F1, F10 nor E1, E2-ATPase. Bafilomycin A1 is useful in distinguishing among different types of ATPases. It is commonly employed to demonstrate the requirement of low endosomal pH for viral uncoating. It can inhibit growth of Capan-1 human pancreatic cancer cells and PC12 cells through apoptosis. Inhibition of V-ATPase by Bafilomycin A1 leads to increase in pH and decreased glycolysis, and thus reduced tumour cell mitosis and proliferation.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Active against gram-positive bacteria and fungi | ATPase inhibitor