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Ampicillin is used to select bacteria cells with specific resistance during general microbiology studies. It is used to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, certain bloodstream infections, and has been used to develop PCR assays to detect resistance genes in cerebrospinal fluid.
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Antibacterial | Antibiotics
|Alternate Names||D[-]-a-Aminobenzylpenicillin; 6-[D(-)-a-Aminophenylacetamido]penicillanic acid|
|Application Notes||Ampicillin is used to select bacteria cells with specific resistance during general microbiology studies. It is used to study antibiotic resistance and penetration limitations, the synergy between multiple antibiotics, certain bloodstream infections, and has been used to develop PCR assays to detect resistance genes in cerebrospinal fluid.|
|Base Catalog Number||190146|
|Beilstein Registry Number||1090925|
|Biochemical Physiological Actions||Ampicillin is a β-lactam antibiotic with an amino group attached to the penicillin structure. Inhibits bacterial cell-wall synthesis (peptidoglycan cross-linking) by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Bactericidal only to growing Escherichia coli. Mode of resistance: Cleavage of β-lactam ring of ampicillin by β-lactamase. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.|
|Melting Point||388 to 392° F (decomposes) (NTP, 1992)|
|Molecular Weight||349.405 g/mol|
|Personal Protective Equipment||Dust mask, Eyeshields, Faceshields, Gloves|
|pKa||pKa = 2.5 (-COOH) pKa = 7.3 (-NH2) at 25 °C|
|Safety Symbol||GHS07, GHS08|
|Solubility||1 to 10 mg/mL at 70° F (NTP, 1992)|
|Typical Working Concentration||100 mg/liter for both gram positive and gram negative bacteria|