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(6R)-5,6,7,8-Tetrahydro-l-biopterin dihydrochloride

(6R)-5,6,7,8-Tetrahydro-l-biopterin dihydrochloride

Synonyms (6R)-BH4-Amino-6-(1,2-dihydroxy-propyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone dihydrochloride; BH4; (6R)-BH4; (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride; Sapropterin; Dapropterin

CAS Number: 17528-72-2 Molecular Formula: C9H15N5O3·2HCl Molecular Weight: 241.251 g/mol

MDL Number: MFCD00891665

SKU 02153622-CF
$211.70
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Description

Product Description

(6R)-5,6,7,8-Tetrahydro-L-Biopterin Dihydrochloride

Application Notes

(6R)-5,6,7,8-Tetrahydro-L-biopterin Dihydrochloride is necessary in vivo for the conversion of phenylalanine to tyrosine and for the production of the hormone epinephrine and of the monoamine neurotransmitters, serotonin, dopamine, and norepinephrine. It is also involved in apoptosis and other cellular events mediated by nitric oxide production and catalyzes the cleavage of alkylglycerol ethers. (6R)-BH4 has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Cofactor

Specifications
SKU 02153622-CF
Alternate Names (6R)-BH4-Amino-6-(1,2-dihydroxy-propyl)-5,6,7,8-tetrahydro-4(1H)-pteridinone dihydrochloride; BH4; (6R)-BH4; (6R)-5,6,7,8-Tetrahydrobiopterin dihydrochloride; Sapropterin; Dapropterin
Application Notes (6R)-5,6,7,8-Tetrahydro-L-biopterin Dihydrochloride is necessary in vivo for the conversion of phenylalanine to tyrosine and for the production of the hormone epinephrine and of the monoamine neurotransmitters, serotonin, dopamine, and norepinephrine. It is also involved in apoptosis and other cellular events mediated by nitric oxide production and catalyzes the cleavage of alkylglycerol ethers. (6R)-BH4 has been used as a buffer component for assaying tyrosine hydroxylase enzyme activity in mouse brain tissues.
Base Catalog Number 153622
Biochemical Physiological Actions Natural cofactor for phenylalanine hydroxylase, tyrosine hydroxylase, tryptophan hydroxylase, and nitric oxide synthetase.
CAS # 17528-72-2
Extinction Coefficient EM(216 nm)=15,400 (0.1 N HCl); (264 nm) = 13,750 (0.1 N HCl)(Lit.)
Format Powder
Hazard Statements H302
Melting Point 250 - 255 °C (hydrochloride salt)
Molecular Formula C9H15N5O3·2HCl
Molecular Weight 241.251 g/mol
Optical Rotation [α]D = -6.6° to –7.6° (C = 1 in 0.1 N HCl)(Lit.)
RTECS Number UO3516000
Safety Symbol GHS07
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.