Background:
A customer providing contract research services encountered variability in dextran sulfate sodium salt (DSS) lots, impacting their pre-clinical drug development studies.
Challenge:
The customer urgently needed to identify an ideal lot of DSS that could consistently induce colitis in mice, as previous lots exhibited unexpected variability. The inconsistencies in weight changes, colon length, and peak weight changes were hindering the progress of critical research studies.
Solution:
Utilizing comprehensive data analysis and close collaboration, we identified a lot that aligned with the customer's desired outcomes based on past successful results. We recommended this lot for evaluation and provided a sample for testing. After extensive testing and comparison, the customer confirmed the lot's successful performance and proceeded with their studies.
Result:
The timely resolution of the DSS variability issue allowed the customer to maintain research continuity without delays. By providing a reliable lot selection based on data analysis, we enabled the customer to make informed decisions and achieve their research goals effectively.