Product Description
Clotrimazole is a specific inhibitor of Ca2+-activated K+ channels. Clotrimazole is an imidazole derivative and antifungal compound which has similar antimicrobial action and activity to ketoconazole.
Application Notes
Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antifungal azole
Specifications
| SKU | 0219894401 |
| Alternate Names | 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole; 1-(o-Chloro-α,α-diphenylbenzyl)imidazole; diphenyl-(2-chlorophenyl)-1-imidazolylmethane |
| Application Notes | Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole. |
| Base Catalog Number | 19894401 |
| Biochemical Physiological Actions | Mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability. |
| CAS # | 23593-75-1 |
| EC Number | 245-764-8 |
| Hazard Statements | H302-H315-H319 |
| Melting Point | 147 - 149 °C (Lit.) |
| Molecular Formula | C22H17ClN2 |
| Molecular Weight | 344.8 |
| Pack Size | 1 g |
| Personal Protective Equipment | Dust mask, Eyeshields, Gloves |
| RTECS Number | NI4377000 |
| Safety Symbol | GHS07 |
| Solubility | Soluble in acetone, chloroform (50 mg/mL), ethyl acetate, DMF, DMSO (25 mM); slightly soluble in water, benzene, toluene. |
| Typical Working Concentration | A concentration of 3μg/mL of clotrimazole is generally effective for inhibiting many fungal species that are sensitive to clotrimazole. |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| UV Visible Absorbance | λmax: 261 nm (Lit.) |
Documents
Certificate of Analysis (COA)
Datasheet
Datasheet