CHAPSO is the hydroxy analog of CHAPS; a nondenaturing zwitterionic detergent for solubilizing proteins, especially integral membrane proteins while maintaining the functional capability of the protein of interest. It has a more polar head group than CHAPS, giving it a greater solubility. CHAPSO has a high CMC (8 mM) and does not denature membrane-bound proteins. It can solubilize the opiate receptor in a state exhibiting reversible binding of opiates.
Choline chloride is an organic compound and a quaternary ammonium salt. It is a weak acid. Choline chloride is the salt of the naturally occurring choline, the pre-stage of the neurotransmitter acetylcholine, which is important for mnemonic and thought-processes. Choline occurs naturally in fungi, hop and kingcups and as integral part of lecithin. Choline chloride is a common food additive in animal husbandry