Retinol(All Trans)
Application Notes
Retinol is an effective antioxidant displaying lipoperoxy radical scavenging activity. The interactions between Retinol and Vitamin E (α-tocopherol) in suppressing lipid peroxidation were observed in bovine retinal membrane preparations. It may influence the production of transition vesicles by stimulating the activity of a protein disulfide isomeraselike activity involved in vesicle formation. Retinol (10 µM) stimulated DNA synthesis and possibly repair mechanisms in Sertoli cells of rat.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antioxidant | Treatment of acute promyelocytic leukemia
| SKU | 02190268-CF |
| Alternate Names | Vitamin A alcohol; Axerophthol; Vitamin A; Vitamin A1; all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; Anti-Infective Vitamin |
| Applications | Antioxidant | Treatment of acute promyelocytic leukemia |
| Application Notes | Retinol is an effective antioxidant displaying lipoperoxy radical scavenging activity. The interactions between Retinol and Vitamin E (α-tocopherol) in suppressing lipid peroxidation were observed in bovine retinal membrane preparations. It may influence the production of transition vesicles by stimulating the activity of a protein disulfide isomeraselike activity involved in vesicle formation. Retinol (10 µM) stimulated DNA synthesis and possibly repair mechanisms in Sertoli cells of rat. |
| Base Catalog Number | 190268 |
| Beilstein Registry Number | 403040 |
| Biochemical Physiological Actions | Ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR) that act as transcription factors to regulate the growth and differentiation of normal and malignant cells. |
| Boiling Point | 279 to 280° F at 1e-06 mm Hg (NTP, 1992) |
| CAS # | 68-26-8 |
| EC Number | 200-683-7 |
| Extinction Coefficient | EM(325nm) = 52,480 (ethanol); E1%(324-325nm) = 1835 (ethanol)(Lit.) |
| Format | Powder |
| Hazard Statements | H302-H315 |
| Melting Point | 144 to 147° F (NTP, 1992) |
| Molecular Formula | C20H30O |
| Molecular Weight | 286.459 g/mol |
| Personal Protective Equipment | Dust mask, Eyeshields, Gloves |
| RTECS Number | VH6750000 |
| Safety Symbol | GHS07 |
| Solubility | Practically insoluble (NTP, 1992) |
| Source | Synthetic |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
| Vapor Pressure | 7.5X10-8 mm Hg at 25 deg C /Estimated/ |
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