Dextran sulfate sodium salt, colitis grade (36,000 - 50,000)
SKU: 02160110-CF
Dextran Sulfate Sodium Salt (DSS), Colitis Grade
For Experimental Colitis and Intestinal Inflammation Research
MP Biomedicals Dextran Sulfate Sodium Salt (DSS), Colitis Grade is a sulfated polysaccharide derived from dextran and widely used in preclinical research to induce experimental intestinal inflammation. The 36,000–50,000 Da molecular weight grade is commonly employed in rodent models designed to investigate mechanisms associated with ulcerative colitis and inflammatory bowel disease (IBD).
When administered according to an approved animal research protocol, DSS can disrupt the intestinal epithelial barrier and trigger colonic inflammation. Disease severity and experimental outcomes depend on factors such as animal strain, dose, exposure schedule, and DSS lot. Model parameters should be established and validated for each study.
Key Research Applications
DSS Colitis Grade supports a range of experimental research models investigating intestinal inflammation, mucosal responses, and disease-associated mechanisms.
- Acute DSS-Induced Colitis: Investigate intestinal inflammation and short-term epithelial injury.
- Chronic DSS-Induced Colitis: Support repeated-cycle experimental models examining persistent inflammation and tissue responses.
- Intestinal Barrier and Mucosal Immunology: Study epithelial integrity, immune responses, and intestinal barrier dysfunction.
- Host–Microbiome Interactions: Explore microbiome-related changes associated with experimental intestinal inflammation.
- Colitis-Associated Colorectal Cancer: Used in combination with azoxymethane (AOM) in established experimental models of inflammation-associated colorectal cancer.
Product Specifications
| Product Name | Dextran Sulfate Sodium Salt (DSS), Colitis Grade |
| Catalog Number | 160110 |
| SG Product Family SKU | 02160110-CF |
| Molecular Weight | 36,000–50,000 Da |
| CAS Number | 9011-18-1 |
| Grade | Colitis Grade |
| pH | 5.0–7.5 (1% aqueous solution) |
| Intended Use | Research or further manufacturing use only. Not for direct human use. |
Explore Colitis Model Research Resources
For additional information on experimental colitis models, study design considerations, and downstream analysis, explore the MP Biomedicals DSS-Induced Colitis resource page and Colitis Model Guidebook.
Researchers investigating inflammation-associated colorectal cancer can also explore complementary Azoxymethane (AOM) products for established experimental research models.
Application Notes
Dextran sulfate sodium (DSS) is one of the most common and effective compounds used for inducing ulcerative colitis in animals. The DSS colitis model has also been used extensively to study colon cancer developing in relation to colonic inflammation, such as that occurring in patients with long-standing ulcerative colitis.
MP Biomedicals offers the gold standard of colitis model creation reagents - colitis grade dextran sulfate sodium salt (36,000-50,000) and colonic carcinogen azoxymethane (AOM).
Because of its high efficacy, MP Biomedical DSS is one of the most widely used DSS products in the scientific literature. Over the past 19 years more than 10,000 scientific publications have cited the use of MP Biomedicals’ DSS products and reported successful animal model establishment.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Acute/ Chronic Ulcerative Colitis Model Induction, Chronic Colitis Associated Colon Cancer Model Induction
| SKU | 02160110-CF |
| Alternate Names | DSS, Dextran Sodium Sulfate |
| Applications | Acute/ Chronic Ulcerative Colitis Model Induction, Chronic Colitis Associated Colon Cancer Model Induction |
| Application Notes |
Dextran sulfate sodium (DSS) is one of the most common and effective compounds used for inducing ulcerative colitis in animals. The DSS colitis model has also been used extensively to study colon cancer developing in relation to colonic inflammation, such as that occurring in patients with long-standing ulcerative colitis. MP Biomedicals offers the gold standard of colitis model creation reagents - colitis grade dextran sulfate sodium salt (36,000-50,000) and colonic carcinogen azoxymethane (AOM). Because of its high efficacy, MP Biomedical DSS is one of the most widely used DSS products in the scientific literature. Over the past 19 years more than 10,000 scientific publications have cited the use of MP Biomedicals’ DSS products and reported successful animal model establishment. |
| Base Catalog Number | 160110 |
| CAS # | 9011-18-1 |
| Grade | Colitis Grade |
| Molecular Weight | 36,000 - 50,000 Da |
| Personal Protective Equipment | Eyeshields, Gloves, respirator filter |
| pH | (1% aqueous solution) 5.0 - 7.5 |
| RTECS Number | HH9290000 |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
1. What is Dextran Sulfate Sodium (DSS), Colitis Grade used for?
DSS Colitis Grade is a research reagent used to establish experimental colitis in rodent models. It supports studies of intestinal inflammation, inflammatory bowel disease (IBD), epithelial barrier disruption, and colitis-associated colorectal cancer.
2. What is the molecular weight of MP Biomedicals DSS Colitis Grade?
The product has a specified molecular weight range of 36,000–50,000 Da (Catalog #160110). Different DSS molecular weight grades may produce different experimental outcomes and should be evaluated when adapting established protocols.
3. Can DSS be used for acute and chronic colitis models?
Yes. DSS is commonly used in experimental acute and repeated-cycle chronic colitis models. Exposure schedules and concentrations depend on the animal model and approved research protocol.
4. How does DSS induce intestinal inflammation in animal models?
In experimental models, DSS can impair the intestinal epithelial barrier, contributing to inflammatory responses in the colon. Model responses vary with experimental conditions and animal characteristics.
5. Can DSS be used in colitis-associated colorectal cancer studies?
Yes. DSS is commonly combined with azoxymethane (AOM) in established experimental models of colitis-associated colorectal cancer. See the MP Biomedicals AOM product and Colitis Model Guidebook for related research resources.
6. Does DSS molecular weight or batch selection affect experimental results?
DSS molecular weight distribution and lot-to-lot variation may influence colitis severity. Where possible, use the same lot throughout a study or perform pilot validation when changing lots. Refer to the lot-specific Certificate of Analysis (CoA).
7. Where can I find DSS-induced colitis protocols and application resources?
MP Biomedicals provides a DSS-Induced Colitis resource page, a Colitis Model Guidebook, and product documentation. Researchers should follow institutionally approved animal-care and experimental protocols.
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