Dino

}{ INOSINE

}{ INOSINE

Synonyms 9-β-D-Ribofuranosylhypoxathine; Hypoxanthine riboside; Hypoxanthosine

CAS Number: 58-63-9 Molecular Formula: C10H12N4O5 Molecular Weight: 268.2

Beilstein Registry Number: 624896 EC Number: 200-390-4 MDL Number: MFCD00066770

Packaging size: 5 g

SKU 0210204905
Price:
$48.35
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Description

Product Description

Inosine is the deaminated form of adenosine. It is a nucleoside consisting of hypoxathine and ribose. Its phosphate ester is inosinic acid. Inosine easily permeates the cell membrane and, taking part in glycolysis and the TCA cycle via the pentose phosphate pathway, elevates the intracellular level of ATP and stimulates biosynthesis of nucleic acids. Adaptation of these metabolic processes activates the cell, and the nucleoside is applicable to various disorders. Inosine accumulates in tissue during periods of ischemia and has been shown to degranulate mast cells in the hamster cheek pouch via activation of an A3 receptor.

Application Notes

Suppresses the increase of glucose and insulin in the blood. Inhibits cytokine production by a posttranscriptional mechanism.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Specifications
SKU 0210204905
Application Notes Suppresses the increase of glucose and insulin in the blood. Inhibits cytokine production by a posttranscriptional mechanism.
Beilstein Registry Number 624896
Biochemical Physiological Actions Inosine is a potent stimulator of nerve growth factor (NGF) induced neurite outgrowth. The elevated levels of inosine in brain following injury are associated with the increased expression proteins related to axonal regeneration and growth. Mice given inosine demonstrated enhanced recovery of fine motor control following ischemic brain damage. Inosine may be used in studies of the process A-to-I RNA editing.
Detection Method FTIR
EC Number 200-390-4
Melting Point 212-213 °C(dec)
Moisture Content ≥0.3%
Molecular Formula C<sub>10</sub>H<sub>12</sub>N<sub>4</sub>O<sub>5</sub>
Molecular Weight 268.2
Pack Size 5 g
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance White Powder
Product Families Description Inosine is the deaminated form of adenosine. It is a nucleoside consisting of hypoxathine and ribose. Its phosphate ester is inosinic acid. Inosine easily permeates the cell membrane and, taking part in glycolysis and the TCA cycle via the pentose phosphate pathway, elevates the intracellular level of ATP and stimulates biosynthesis of nucleic acids. Adaptation of these metabolic processes activates the cell, and the nucleoside is applicable to various disorders. Inosine accumulates in tissue during periods of ischemia and has been shown to degranulate mast cells in the hamster cheek pouch via activation of an A3 receptor.
Purity ≥99.0%
Related Products 05213661
RTECS Number NM7460000
Solubility Soluble in 1 N HCl (30 mg/mL - clear, colorless solution), 50% ammonium hydroxide (10 mg/mL - clear, colorless solution); Slightly soluble in water (1.6 g/100 mL at 20°C); very slightly soluble in ethanol or chloroform; practically insoluble in ether.
Storage and Handling Store at Room Temperature(15-30 °C).
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance UV/Vis: λ max (water): 248 ± 3nm; OD250/OD260: 1.49 - 1.81; OD280/OD260: 0.21 - 0.31; OD290/OD260: 0.01 - 0.05