Ac-Lys-Pro-Arg-7-Amino-4-Trifluoromethylcoumarin is an fluorescent substrate for Tryptase detection. Tryptases are a group of trypsin-related serine proteases expressed in mast cells and basophils.
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Substrate for Assay of Tryptase
|Alternate Names||Ac-Lys-Pro-Arg-AFC; Ac-KPR-AFC|
|Application Notes||Ac-Lys-Pro-Arg-7-Amino-4-Trifluoromethylcoumarin is an fluorescent substrate for Tryptase detection. Tryptases are a group of trypsin-related serine proteases expressed in mast cells and basophils.|
|Base Catalog Number||AFC13025|
|CAS #||Not yet assigned|
|Pack Size||25 mg|
|Protein or Enzyme Type||Activators, Inhibitors & Substrates|
|Specificity||Other trypsin-like enzymes are cleaved by tripeptide synthetic substrates. The absence of inhibition of Tryptase by classical inhibitors or serine esterase; including soybean trypsin inhibitor; clearly distinguishes tryptase from pancreatic trypsin and from most other serine esterases. Tryptase is inhibited by leupeptin; PMSF; and diisopropyl fluorophosphate.|
|Unit Definition||One unit is the amount of enzyme that cleaves one micromole of AFC, AMC or MNA per minute, per milliliter at above described conditions.|