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Sodium Orthovanadate is used in the diabetes study. Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase. It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.
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Alkaline phosphate inhibitor
|Alternate Names||Decavanadate; Sodium Vanadate; Sodium Vanadium Oxide|
|Application Notes||Sodium Orthovanadate is used in the diabetes study. Sodium orthovandate was used to prepare the stop solution in dephosphorylation assay of insulin receptor kinase. It was one of the reagents used in the development of Matrix ChIP that utilizes surface-immobilized antibodies.|
|Base Catalog Number||159664|
|Biochemical Physiological Actions||Inhibits ATPase, alkaline phosphatase and tyrosine phosphatase. Decavanadate, which is formed at acidic pH, inhibits inositol 1,4,5-trisphosphate (IP3)-induced Ca2+ release from endocrine cells and blocks IP3 binding to its receptor in brain tissue.Sodium orthovandate suppresses the activation of p53-mediated apoptosis triggered in response to radiation. It reduces the detrimental effects of hematopoietic syndrome, hematopoiesis and delayed genotoxic effects of induced by total body irradiation of mice. In combination with menadione, orthovandate prevents the migration of detached human glioma cells in response to anti-cancer drugs.|
|Hazard Statements||H302 + H312 + H332|
|Molecular Weight||183.907 g/mol|
|Personal Protective Equipment||Dust mask , Eyeshields, Faceshields, Gloves|