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Pepstatin A

Pepstatin A
€33.70

Key features and details

  • Reversible inhibitor of acid proteases
  • Does not inhibit thiol proteases, neutral proteases or serine proteases
  • Forms a 1:1 complex with acid proteases (carboxyl proteases)

SKU: 02195368-CF

Synonyms
Isovaleryl-L-valyl-L-valyl-[(3S, 4S)-4-amino-3-hydroxy-6- methylheptanoyl]-L- alanyl [3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid]; [1S-[1R*,2R*,4[R*[R*(R*)]]]]-N- (3-methyl-1-oxobutyl)-L-valyl-N-[4-[[2-[[1-(2-carboxy-1-hydroxyethyl)-3- methylbutyl] amino]-1-methyl-2-oxoethyl]amino]-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide; N-isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-g-aminoheptanoyl-L- alanyl-3-hydroxy-6-methyl-g-aminoheptanoic acid
CAS Number:
26305-03-3
Molecular Formula:
C34H63N5O9
Beilstein Registry Number:
2201362
EC Number:
247-600-0
MDL Number:
MFCD00060740
Product Description

Pepstatin A

Application Notes

Pepstatin A can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Inhibition | Protein Inhibitor

Specifications
SKU 02195368-CF
Alternate Names Isovaleryl-L-valyl-L-valyl-[(3S, 4S)-4-amino-3-hydroxy-6- methylheptanoyl]-L- alanyl [3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid]; [1S-[1R*,2R*,4[R*[R*(R*)]]]]-N- (3-methyl-1-oxobutyl)-L-valyl-N-[4-[[2-[[1-(2-carboxy-1-hydroxyethyl)-3- methylbutyl] amino]-1-methyl-2-oxoethyl]amino]-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide; N-isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-g-aminoheptanoyl-L- alanyl-3-hydroxy-6-methyl-g-aminoheptanoic acid
Application Notes Pepstatin A can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes.
Base Catalog Number 195368
Beilstein Registry Number 2201362
Biochemical Physiological Actions Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized γ-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources.
CAS # 26305-03-3
EC Number 247-600-0
Hazard Statements H317
Molecular Formula C34H63N5O9
Personal Protective Equipment Eyeshields, Gloves,respirator filter
RTECS Number SC6155000
Typical Working Concentration Effective concentration is approximately 1 uM (0.5 to 1.0 ug/mL).
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Certificate of Analysis (COA)