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Pepstatin A can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes.
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Inhibition | Protein Inhibitor
|Alternate Names||Isovaleryl-L-valyl-L-valyl-[(3S, 4S)-4-amino-3-hydroxy-6- methylheptanoyl]-L- alanyl [3S,4S)-4-amino-3-hydroxy-6-methylheptanoic acid]; [1S-[1R*,2R*,4[R*[R*(R*)]]]]-N- (3-methyl-1-oxobutyl)-L-valyl-N-[4-[[2-[[1-(2-carboxy-1-hydroxyethyl)-3- methylbutyl] amino]-1-methyl-2-oxoethyl]amino]-2-hydroxy-1-(2-methylpropyl)-4-oxobutyl]-L-valinamide; N-isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-g-aminoheptanoyl-L- alanyl-3-hydroxy-6-methyl-g-aminoheptanoic acid|
|Application Notes||Pepstatin A can be used in conjunction with E64-d and Leupeptin A to inhibit the degradation of autophagic cargo inside autophagosomes.|
|Base Catalog Number||195368|
|Beilstein Registry Number||2201362|
|Biochemical Physiological Actions||Pepstatin A is an inhibitor of acid proteases (aspartyl peptidases). It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B (Aspergillus niger). The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized γ-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources.|
|Personal Protective Equipment||Eyeshields, Gloves,respirator filter|
|Typical Working Concentration||Effective concentration is approximately 1 uM (0.5 to 1.0 ug/mL).|
|Usage Statement||Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.|