Lactacystin, 200 UG

Lactacystin, 200 UG

CAS Number: 133343-34-7 Molecular Formula: C15H24N2O7S Molecular Weight: 376.4

Packaging size: 200 UG

SKU 0219586382
Price:
€212.00
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Description

Product Description

Induces neuritogenesis. Potent and selective irreversible proteasome inhibitor. Specifically inhibits 20S proteasome (MCP; multicatalytic complex). Blocks proteasome activity by targeting the catalytic β-subunit. Apoptosis inducer. Anticancer compound. Upregulates HSP70 and HSP22. Induces differentiation and inhibits cell cycle progression in several tumor cell lines. Inhibits NF-κB activation by inhibiting IκB degradation. Cathepsin A inhibitor. β-Secretase activity inhibitor. Anti-adipogenic. Autophagy inducer.

Application Notes

Ubiquitination-Proteasome, Apoptosis, Cancer, Cell Biology, Enzyme Inhibitor, Autophagy

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Specifications
SKU 0219586382
Application Notes Ubiquitination-Proteasome, Apoptosis, Cancer, Cell Biology, Enzyme Inhibitor, Autophagy
Base Catalog Number 19586382
CAS # 133343-34-7
Molecular Formula C15H24N2O7S
Molecular Weight 376.4
Pack Size 200 UG
Physical Appearance White to off-white solid.
Product Families Description Synthetic Cell permeable 20S proteasome inhibitor. Induces neurite outgrowth in mouse neuroblastoma cells and inhibits progression of synchronized Neuro 2A cells and MG-63 human osteosarcoma cells beyond the G1 phase. Appears to induce apoptosi
Solubility Soluble in water, methanol, ethanol, DMSO, pyridine, acetonitrile or dimethyl formamide. Insoluble in hexane, benzene, chloroform or ethyl acetate.
Storage and Handling Store at -20 °C for up to 3 years.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.