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Clozapine, 10 mg

Clozapine, 10 mg
€63.20

SKU: 0215976010

Synonyms
HF1854; Clozaril; Clorazil; Leponex; Lepotex; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; Iprox; W-801
CAS Number:
5786-21-0
Molecular Formula:
C18H19N4Cl
Molecular Weight:
326.83
EC Number:
227-313-7
MDL Number:
MFCD00153785
Packaging size:
10 mg
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Product Description

Clozapine is a dibenzodiazepine compound, structurally related to loxapine is used in cell signaling research. It is an a typical antipsychotic medication used in the treatment of schizophrenia. It is a dopamine D4 and D2 receptor antagonist which has high affinity for the cloned rat dopamine D4 receptor (Ki < 20 nM). It is also a potent, selective muscarinic antagonist which exhibits the highest reported affinity for 5-HT1A and 5-HT1C sites.

Application Notes

Clozapine has dopamine receptor blocking activity, α-adrenergic blocking, antimuscarinic, antihistamine, and antiserotonergic properties. The role of clozapine in reversing the inhibitory effect of dopamine on sodium and water transport in the rat cortical collecting duct has been reviewed. Clozapine has been used to probe the role of the calcium/calmodulin-dependent kinase II in NMDA-induced inward currents and electrically evoked excitatory postsynaptic currents in mouse brain sections, cultured mouse cells, and transgenic mice.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Blocking of dopamine receptor

Specifications
SKU 0215976010
Alternate Names HF1854; Clozaril; Clorazil; Leponex; Lepotex; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; Iprox; W-801
Application Notes Clozapine has dopamine receptor blocking activity, α-adrenergic blocking, antimuscarinic, antihistamine, and antiserotonergic properties. The role of clozapine in reversing the inhibitory effect of dopamine on sodium and water transport in the rat cortical collecting duct has been reviewed. Clozapine has been used to probe the role of the calcium/calmodulin-dependent kinase II in NMDA-induced inward currents and electrically evoked excitatory postsynaptic currents in mouse brain sections, cultured mouse cells, and transgenic mice.
Base Catalog Number 15976010
Biochemical Physiological Actions A typical antipsychotic compound. Selective antagonist for D4- dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors.
CAS # 5786-21-0
EC Number 227-313-7
Extinction Coefficient Ethanol: 27.4 (215 nm), 25.8 (230 nm), 16.8 (261 nm), 10.5 (297 nm) (Lit.)
Hazard Statements H301-H341-H361
Melting Point 182-184 °C (lit.)
Molecular Formula C18H19N4Cl
Molecular Weight 326.83
Pack Size 10 mg
RTECS Number HP1750000
Safety Symbol GHS06, GHS08
Solubility Soluble in 0.1M HC1 (25 mg/mL), ethanol (1 mg/mL) or DMSO (100 mM).
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Datasheet

Datasheet
DS [02159760] DS [02159760]