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Product Description
α2-Macroglobulin
Application Notes
α2-Macroglobulin inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. It inhibits bromelain, chymotrypsin, elastase, endoproteinase Arg-C, endoproteinase Glu-C, ficin, papain, plasmin, subtilisin, thermolysin, thrombin, and trypsin. It is known to inhibit neurite outgrowth by blocking the activity of b-nerve growth factor.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Inhibitor
Specifications
| SKU | 0219134505 |
| Alternate Names | α2-M;α2-Macroglobulin |
| Application Notes | α2-Macroglobulin inhibits all classes of endoproteases by forming a complex with the protease. When the protease cleaves the macroglobulin "bait" sequence, the macroglobulin rearranges and traps the protease. It inhibits bromelain, chymotrypsin, elastase, endoproteinase Arg-C, endoproteinase Glu-C, ficin, papain, plasmin, subtilisin, thermolysin, thrombin, and trypsin. It is known to inhibit neurite outgrowth by blocking the activity of b-nerve growth factor. |
| Base Catalog Number | 19134505 |
| Biochemical Physiological Actions | One mg of α2-macroglobulin will inhibit a minimum of 10 μg trypsin with an activity of 10,000 BAEE un/mg protein. α2-Macroglobulin is found abundantly in plasma and interstitial fluids. The protease-α2-M balance plays an important role in mediating inflammatory tissue destruction. Serum levels of α2-M and protease-α2-M complexes are increased in patients with sepsis, emphysema, periodontitis, rheumatoid arthritis, and other inflammatory diseases, and oxidant inactivation of α2-M may contribute to tissue destruction during inflammation. |
| CAS # | Not applicable |
| Format | Crystalline powder |
| Formulation Details | Lyophilized from 490 µL 30 mM Na phosphate; pH 7.0 and 10 mg Glucine and 1 mg glycine. |
| Pack Size | 5 mg |
| Purity | ≥95% (SDS-PAGE) |
| Source | Human plasma |
| Usage Statement | Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department. |
Documents
Datasheet
Datasheet
![DS [02191345]](https://www.mpbio.com/static/version1656588924/frontend/Mpbio/default/en_US/images/document.png "DS [02191345]")
Citations