4-Aminopyridine, 5 g

Specifications

SKU	0215036605
Alternate Names	Amino-4-Pyridine; γ-Aminopyridine; 4-Pyridinamine, 4-Pyridylamine; Fampridine; 4AP
Application Notes	4-Aminopyridine (4-AP) is a nonselective K+ channel blocker that has been used to characterize and study the blockage of K+ channels. Studies show that 4-AP binds from the cytoplasmic side of the cell membrane. Research suggest that 4-AP extends the potentials of unmyelinated and demyelinated fibers, facilitates conduction in fibers blocked by demyelination, and can induce glutamate and neurotransmitter γ-aminobutyric acid (GABA) release.
Base Catalog Number	15036605
Beilstein Registry Number	105782
Biochemical Physiological Actions	4-aminopyridine (4-AP) is a non-selective potassium channel blocker. It reverses saxitoxin and tetrodotoxin induced cardiorespiratory depression. 4-AP increases stimulation-induced release of acetylcholine and induces depolarization of GABA neurons.
Boiling Point	273 °C (Lit.)
CAS #	504-24-5
EC Number	207-987-9
Extinction Coefficient	EmM = 16.6 (0.1 M HCl), 17.4 (0.1 M HCl)(Lit.)
Hazard Statements	H300-H315-H319-H335
Melting Point	153 -163 °C
Molecular Formula	C₅H₆N₂
Molecular Weight	94.13
Pack Size	5 g
Personal Protective Equipment	Dust mask, Eyeshields, Faceshields, Gloves, respirator cartridges
pH	10.5 - 11.5 (1% aq. soln.)
Purity	~98%
RTECS Number	US1750000
Safety Symbol	GHS06
Solubility	Soluble in water (50 mg/mL - clear and colorless), 100% ethanol, methanol (slightly), alcohol, and DMSO (100 mM), slightly soluble in benzene, ether; very slighly soluble in ligroin.
Usage Statement	Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance	λ max: 263 nm (0.1 M HCl), 262 nm (0.1 M HCl)(Lit.)

Documents

Datasheet

DS [02150366]

Citations