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4-Aminopyridine, 5 g

4-Aminopyridine, 5 g

SKU: 0215036605

Amino-4-Pyridine; γ-Aminopyridine; 4-Pyridinamine, 4-Pyridylamine; Fampridine; 4AP
CAS Number:
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Molecular Weight:
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EC Number:
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Packaging size:
5 g
SKU 0215036605
Alternate Names Amino-4-Pyridine; γ-Aminopyridine; 4-Pyridinamine, 4-Pyridylamine; Fampridine; 4AP
Application Notes 4-Aminopyridine (4-AP) is a nonselective K+ channel blocker that has been used to characterize and study the blockage of K+ channels. Studies show that 4-AP binds from the cytoplasmic side of the cell membrane. Research suggest that 4-AP extends the potentials of unmyelinated and demyelinated fibers, facilitates conduction in fibers blocked by demyelination, and can induce glutamate and neurotransmitter γ-aminobutyric acid (GABA) release.
Base Catalog Number 15036605
Beilstein Registry Number 105782
Biochemical Physiological Actions 4-aminopyridine (4-AP) is a non-selective potassium channel blocker. It reverses saxitoxin and tetrodotoxin induced cardiorespiratory depression. 4-AP increases stimulation-induced release of acetylcholine and induces depolarization of GABA neurons.
Boiling Point 273 °C (Lit.)
CAS # 504-24-5
EC Number 207-987-9
Extinction Coefficient EmM = 16.6 (0.1 M HCl), 17.4 (0.1 M HCl)(Lit.)
Hazard Statements H300-H315-H319-H335
Melting Point 153 -163 °C
Molecular Formula C5H6N2
Molecular Weight 94.13
Pack Size 5 g
Personal Protective Equipment Dust mask, Eyeshields, Faceshields, Gloves, respirator cartridges
pH 10.5 - 11.5 (1% aq. soln.)
Purity ~98%
RTECS Number US1750000
Safety Symbol GHS06
Solubility Soluble in water (50 mg/mL - clear and colorless), 100% ethanol, methanol (slightly), alcohol, and DMSO (100 mM), slightly soluble in benzene, ether; very slighly soluble in ligroin.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance λ max: 263 nm (0.1 M HCl), 262 nm (0.1 M HCl)(Lit.)