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Wortmannin

Wortmannin

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Wortmannin

SKU: 02195690-CF

Synonyms
[1s-(1a,6ba,9ab,11a,11bb)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-7,9,a,11b-dimethyl-3-furo (4,3,2-de)indeno[4,5,-h]-2-benzopyran-3,6,9-trione; KY 12420
CAS Number:
19545-26-7
Molecular Formula:
C23H24O8
Molecular Weight:
428.437 g/mol
Beilstein Registry Number:
67676
MDL Number:
MFCD00133927
Product Description

Wortmannin

Application Notes

Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Phosphatidylinositol 3-kinase (PI3-K) inhibitor

Specifications
SKU 02195690-CF
Alternate Names [1s-(1a,6ba,9ab,11a,11bb)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-7,9,a,11b-dimethyl-3-furo (4,3,2-de)indeno[4,5,-h]-2-benzopyran-3,6,9-trione; KY 12420
Application Notes Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.
Base Catalog Number 195690
Beilstein Registry Number 67676
Biochemical Physiological Actions Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
CAS # 19545-26-7
Format Powder
Hazard Statements H300-H310-H330
Molecular Formula C23H24O8
Molecular Weight 428.437 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
RTECS Number CB9641000
Safety Symbol GHS06
Source Penicillium wortmannii
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Certificates of Analysis

Certificates of Analysis
English (United States)
Certificates of Analysis
English (United States)
Certificates of Analysis
English (United States)
Certificates of Analysis
English (United States)
Certificates of Analysis
English (United States)

Datasheets

Datasheets
English (United States)

Material Safety Data Sheet

Material Safety Data Sheet
English (United States)