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Tunicamycin

Tunicamycin

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Tunicamycin

SKU: 02150028-CF

CAS Number:
11089-65-9
Molecular Weight:
816.899 g/mol
Beilstein Registry Number:
6888090
MDL Number:
MFCD00065709
Product Description

Tunicamycin

Application Notes

Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells[7]. Tunicamycin has also been used to study the functional effects of coxsackievirus and adenovirus receptor (CAR) glycosylation in COS-7 cells.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotic | Study of microbial biosynthetic mechanisms

Specifications
SKU 02150028-CF
Application Notes Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells[7]. Tunicamycin has also been used to study the functional effects of coxsackievirus and adenovirus receptor (CAR) glycosylation in COS-7 cells.
Base Catalog Number 150028
Beilstein Registry Number 6888090
Biochemical Physiological Actions Tunicamycin inhibits many biochemical functions such as synthesis of glycoproteins, procollagen, and peptidoglycans; and IgA and IgE secretion by plasma cells. Blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. Inhibits bacterial and eukaryote N-acetylglucosamine transferases and prevents formation of N-acetylglucosamine lipid intermediates. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also affects the fibroblast interferon-cell system.
CAS # 11089-65-9
Format Powder
Hazard Statements H300
Molecular Weight 816.899 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
RTECS Number YO7980200
Safety Symbol GHS06
Source Streptomyces sp.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
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