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Trimethoprim

Trimethoprim

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Trimethoprim

SKU: 02195527-CF

Synonyms
2,4-Diamino-5-[3,4,5-trimethoxybenzyl]pyrimidine; 5-[(3,4,5-Trimethoxyphenyl) methyl]-2,4-pyrimidinediamine
CAS Number:
738-70-5
Molecular Formula:
C14H18N4O3
Molecular Weight:
290.323 g/mol
Beilstein Registry Number:
625127
EC Number:
212-006-2
MDL Number:
MFCD00036761
Product Description

Trimethoprim

Application Notes

Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibacterial

Specifications
SKU 02195527-CF
Alternate Names 2,4-Diamino-5-[3,4,5-trimethoxybenzyl]pyrimidine; 5-[(3,4,5-Trimethoxyphenyl) methyl]-2,4-pyrimidinediamine
Application Notes Trimethoprim is primarily used as an antibacterial agent. It has dihydrofolate reductase inhibitor activity with selectivity for the prokaryote enzyme. It is used to treat urinary tract infections, mild acute prostatitis, recurrent cystitis, asymptomatic bacteriuria during pregnancy and respiratory tract infections.
Base Catalog Number 195527
Beilstein Registry Number 625127
Biochemical Physiological Actions The combination of trimethoprim and sulfamethoxazole interferes with the cellular metabolism of folic acid in the bacterial cell by blocking the biosynthesis of nucleotides. Trimethoprim binds to dihydrofolate reductase and inhibits the reduction of dihydrofolic acid (DHF) to tetrahydrofolic acid (THF). THF is an essential precursor in the thymidine synthesis pathway and interference with this pathway inhibits bacterial DNA synthesis.
CAS # 738-70-5
EC Number 212-006-2
Melting Point 390 to 397° F (NTP, 1992)
Molecular Formula C14H18N4O3
Molecular Weight 290.323 g/mol
Personal Protective Equipment Eyeshields, Gloves, respirator filter
RTECS Number UV8225000
Solubility less than 1 mg/mL at 75° F (NTP, 1992)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Certificates of Analysis

Certificates of Analysis
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Certificates of Analysis
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Certificates of Analysis
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Certificates of Analysis
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Certificates of Analysis
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Certificates of Analysis
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Certificates of Analysis
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Datasheets

Datasheets
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Material Safety Data Sheet

Material Safety Data Sheet
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Material Safety Data Sheet
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Material Safety Data Sheet
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Material Safety Data Sheet
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Material Safety Data Sheet
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Material Safety Data Sheet
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Material Safety Data Sheet
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Material Safety Data Sheet
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