Tetracycline, hydrochloride, cell culture reagent

Tetracycline, hydrochloride, cell culture reagent

Synonyms Achromycin HCl; Polucycline HCl; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a- octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide hydrochloride; Achro; Achromycin;, Achromycin V;, Ala Tet; Ambracyn; Ambramicina; Bristaciclina; Cefracycline; Criseociclina; Cyclopar; Diocyclin; Helvecyclin; Hostacyclin; Imex; Mediletten; Mephacyclin; Panmycin; Partrex; Polycycline; Purocyclina; Quadracyclin; Remicyclin; Riocyclin; Ro-Cycline; Sanclomycine; Steclin; Sumycin; Supramycin; Sustamycin; Tefilin; Tetrabakat; Tetrabid; Tetrablet; Tetrabon; Tetrachel; Tetracompren; Tetracyn; Tetrakap; Tetralution; Tetramavan; Tetramycin; Tetrosol; Topicycline; Totomycin; Triphacyclin; Unicin; Vetquamycin-324

CAS Number: 64-75-5 Molecular Formula: C22H24N2O8·HCl Molecular Weight: 480.898 g/mol

Beilstein Registry Number: 3844873 EC Number: 200-593-8 MDL Number: MFCD00078142

SKU 02194542-CF
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Description

Product Description

Tetracycline Hydrochloride

Application Notes

Tetracycline hydrochloride is used in tetracycline controlled gene expression systems (gene switches) such a the tet-on and tet-off systems.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Used in tetracycline controlled gene expression systems

Specifications
SKU 02194542-CF
Alternate Names Achromycin HCl; Polucycline HCl; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a- octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide hydrochloride; Achro; Achromycin;, Achromycin V;, Ala Tet; Ambracyn; Ambramicina; Bristaciclina; Cefracycline; Criseociclina; Cyclopar; Diocyclin; Helvecyclin; Hostacyclin; Imex; Mediletten; Mephacyclin; Panmycin; Partrex; Polycycline; Purocyclina; Quadracyclin; Remicyclin; Riocyclin; Ro-Cycline; Sanclomycine; Steclin; Sumycin; Supramycin; Sustamycin; Tefilin; Tetrabakat; Tetrabid; Tetrablet; Tetrabon; Tetrachel; Tetracompren; Tetracyn; Tetrakap; Tetralution; Tetramavan; Tetramycin; Tetrosol; Topicycline; Totomycin; Triphacyclin; Unicin; Vetquamycin-324
Application Notes Tetracycline hydrochloride is used in tetracycline controlled gene expression systems (gene switches) such a the tet-on and tet-off systems.
Base Catalog Number 194542
Beilstein Registry Number 3844873
Biochemical Physiological Actions Mode of Action: Inhibits protein synthesis (elongation) by preventing binding of aminoacyl-tRNA to the 30S subunit. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria. Mode of Resistance: Loss of cell wall permeability.
CAS # 64-75-5
EC Number 200-593-8
Extinction Coefficient EMm (220nm) = 13 (free base in 0.1 M HCl); EmM (268nm) = 18.04 (free base in 0.1 M HCl); EmM (355nm) = 13.32 (free base in 0.1 M HCl)(Lit.)
Format Powder
Grade Cell Culture Grade
Hazard Statements H315-H319-H335
Melting Point 417° F (decomposes) (NTP, 1992)
Molecular Formula C22H24N2O8·HCl
Molecular Weight 480.898 g/mol
Optical Rotation -239 ° to -258 ° (c=0.01, 0.1 N HCl)
Personal Protective Equipment Dust mask, Eyeshields, Gloves
pH 3.0-7.0 /saturated solution/
pKa pKa (50% aq DMF): 8.3, 10.2 (Lit.)
Potency ≥900 µg/mg
RTECS Number QI9100000
Safety Symbol GHS07
Solubility 50 to 100 mg/mL at 72° F (NTP, 1992)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance λ max (1N HCl) 219, 271, 357 ± 5 nm