四环素

四环素

Synonyms Abramycin; Bristacycline; Democracin; Sanclomycine; Tetraverine; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a- octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide; deschlorobiomycin; tsiklomitsin; Abricycline; Bio-Tetra; Cyclomycin; Dumocyclin; Tetradecin.

CAS Number: 60-54-8 Molecular Formula: C22H24N2O8 Molecular Weight: 444.44 g/mol

Beilstein Registry Number: 2230417 EC Number: 200-481-9 MDL Number: MFCD00151232

SKU 02103012-CF
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Description

Product Description

Tetracycline

Application Notes

Tetracyline inhibits gram-positive, gram-negative and mycoplasma. It is used in tetracycline controlled gene expression systems (gene switches) such as the tet-on and tet-off systems. It is also used to select tetracyline resistant colonies in cell culture.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotic | Used in tetracycline controlled gene expression systems | Used to select tetracyline resistant colonies

Specifications
SKU 02103012-CF
Alternate Names Abramycin; Bristacycline; Democracin; Sanclomycine; Tetraverine; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a- octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide; deschlorobiomycin; tsiklomitsin; Abricycline; Bio-Tetra; Cyclomycin; Dumocyclin; Tetradecin.
Application Notes Tetracyline inhibits gram-positive, gram-negative and mycoplasma. It is used in tetracycline controlled gene expression systems (gene switches) such as the tet-on and tet-off systems. It is also used to select tetracyline resistant colonies in cell culture.
Base Catalog Number 103012
Beilstein Registry Number 2230417
Biochemical Physiological Actions Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
CAS # 60-54-8
EC Number 200-481-9
Format Powder
Hazard Statements H302
Melting Point 417° F (decomposes) (NTP, 1992)
Molecular Formula C22H24N2O8
Molecular Weight 444.44 g/mol
Optical Rotation [α]20/D −230±5°, c = 1% in methanol
Personal Protective Equipment Dust mask, Eyeshields, Gloves
pH 3.0-7.0 /saturated solution/
pKa 8.3, 10.2(50% aq DMF)(lit.)
Potency ≥900 µg/mg
RTECS Number QI8750000
Safety Symbol GHS07
Solubility 50 to 100 mg/mL at 72° F (NTP, 1992)
Source Streptomyces spp
Typical Working Concentration 10 ug/mL
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance λmax (0.1N HCl) 217-220, 268-271, 355-356 nm