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嘌呤霉素

嘌呤霉素

CN¥687.05
CAS:58-58-2 嘌呤霉素二盐酸盐, 二氢氯化嘌呤毒素

SKU: 02194539-CF

Synonyms
Stylomycin ; 6-dimethylamino-9-(3'-deoxy-3'-(p-methoxy-L-phenylalanyamino)- B-D-ribofuranosyl)-purine; 3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine dihydrochloride
CAS Number:
58-58-2
Molecular Formula:
C22H29N7O5-2HCl
Molecular Weight:
544.40
Beilstein Registry Number:
3853613
EC Number:
200-387-8
MDL Number:
MFCD00012691
Product Description

An aminonucleoside antibiotic that is toxic to both prokaryotic and eukaryotic cells. It causes premature chain termination in protein synthesis and is widely used in cell culture as a selection agent.

Application Notes

Puromycin can be used in vitro as a selection agent for cells transfected with puromycin N-acetyl transferase gene (pac). It causes premature chain termination in protein synthesis, and is an inhibitor of aminopeptidase and enkephalinase.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Inhibitor of aminopeptidase and enkephalinase.

Specifications
SKU 02194539-CF
Alternate Names Stylomycin ; 6-dimethylamino-9-(3'-deoxy-3'-(p-methoxy-L-phenylalanyamino)- B-D-ribofuranosyl)-purine; 3′-[α-Amino-p-methoxyhydrocinnamamido]-3′-deoxy-N,N-dimethyladenosine dihydrochloride
Application Notes Puromycin can be used in vitro as a selection agent for cells transfected with puromycin N-acetyl transferase gene (pac). It causes premature chain termination in protein synthesis, and is an inhibitor of aminopeptidase and enkephalinase.
Base Catalog Number 194539
Beilstein Registry Number 3853613
Biochemical Physiological Actions Mode of Action: Puromycin inhibits protein synthesis by causing premature chain termination acting as an analog of the 3'-terminal end of the aminoacyl-tRNA.Mode of Resistance: Puromycin acetyltransferase is an effective resistance gene.Antimicrobial Spectrum: This product is active against gram-positive microorganisms, less active against acid-fast bacilli and more weakly active against gram-negative microorganisms. Puromycin can prevent growth of bacteria, protozoa, algae and mammalian cells and acts quickly, killing 99% of cells within 2 days.
CAS # 58-58-2
EC Number 200-387-8
Format Powder
Grade Cell Culture Grade
Hazard Statements H302
Molecular Formula C22H29N7O5-2HCl
Molecular Weight 544.40
Personal Protective Equipment Dust mask , Eyeshields, Gloves
RTECS Number AU7355000
Safety Symbol GHS07
Solubility Soluble (NTP, 1992)
Typical Working Concentration recommended working concentration in eukaryotic cell culture is 1-10 µg/mL
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance λ max (0.1N HCl) 268 ± 2 nm
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