嘌呤霉素

嘌呤霉素

Synonyms 6-dimethylamino-9-(3'-deoxy-3'-(p-methoxy-L-phenylalanyamino)- B-D-ribofuranosyl)-purine

CAS Number: 58-58-2 Molecular Formula: C22H29N7O5 · 2HCl Molecular Weight: 544.434 g/mol

Beilstein Registry Number: 3853613 EC Number: 200-387-8 MDL Number: MFCD00012691

SKU 02100552-CF
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Description

Product Description

Puromycin Dihydrochloride

Application Notes

Puromycin is Nucleoside antibiotic & protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3′-terminal end of aminoacyl-tRNA. Prevents growth of bacteria, protozoa, algae, and mammalian cells.Puromycin dihydrochloride is a part of the amino-nucleoside family of antibiotics and is derived from Streptomyces alboniger. It is a broad spectrum antibiotic with antitumor activity, as an inhibitor of protein synthesis and has been used to study transcription regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotic

Specifications
SKU 02100552-CF
Alternate Names 6-dimethylamino-9-(3'-deoxy-3'-(p-methoxy-L-phenylalanyamino)- B-D-ribofuranosyl)-purine
Application Notes Puromycin is Nucleoside antibiotic & protein synthesis inhibitor that causes premature chain termination by acting as an analog of the 3′-terminal end of aminoacyl-tRNA. Prevents growth of bacteria, protozoa, algae, and mammalian cells.Puromycin dihydrochloride is a part of the amino-nucleoside family of antibiotics and is derived from Streptomyces alboniger. It is a broad spectrum antibiotic with antitumor activity, as an inhibitor of protein synthesis and has been used to study transcription regulatory mechanisms that control the sequential and coordinate expression of genes during cell differentiation.
Base Catalog Number 100552
Beilstein Registry Number 3853613
Biochemical Physiological Actions Mode of Action: Puromycin inhibits protein synthesis by causing premature chain termination acting as an analog of the 3'-terminal end of the aminoacyl-tRNA.Mode of Resistance: Puromycin acetyltransferase is an effective resistance gene.Antimicrobial Spectrum: This product is active against gram-positive microorganisms, less active against acid-fast bacilli and more weakly active against gram-negative microorganisms. Puromycin can prevent growth of bacteria, protozoa, algae and mammalian cells and acts quickly, killing 99% of cells within 2 days.
CAS # 58-58-2
EC Number 200-387-8
Extinction Coefficient 20.3 (275 nm, 0.1 N NaOH), 19.5 (268 nm, 0.1 NHCl) (Lit.)
Hazard Statements H302
Molecular Formula C22H29N7O5 · 2HCl
Molecular Weight 544.434 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Gloves
pKa 6.8, 7.2 (Lit.)
RTECS Number AU7355000
Safety Symbol GHS07
Solubility Soluble (NTP, 1992)
Source Streptomyces albo-niger
Typical Working Concentration The recommended working concentration in eukaryotic cell culture is 1-10 µg/mL.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance 268 ± 2 nm (λ max (0.1N HCl)