Prostaglandin E2 is use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Study of prostaglandin regulated cell signaling and gene regulation
|Alternate Names||[5Z,11a,13E,15S]-11,15-Dihydroxy-9-oxoprosta-5,13-dien-1-oic acid; PGE2; Dinoprostone|
|Application Notes||Prostaglandin E2 is use in cell culture applications for the study of prostaglandin regulated cell signaling and gene regulation.|
|Base Catalog Number||19457601|
|Beilstein Registry Number||4709356|
|Biochemical Physiological Actions||Most biologically active prostaglandin. PGE2 induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE2-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE2 on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.|
|Melting Point||67 °C|
|Molecular Weight||352.471 g/mol|
|Pack Size||1 mg|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge,respirator filter|
|Safety Symbol||GHS07, GHS08|
|Solubility||Water Solubility58.1 mg/L|
|Usage Statement||Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.|