Cart
 
Inquire

Okadaic acid, sodium salt, 10 UG

Okadaic acid, sodium salt, 10 UG

CN¥0.00

SKU: 0215897410

Synonyms
OA; 9,10-deepithio-9,10-didehydroacanthifolicin
CAS Number:
78111-17-8
Molecular Formula:
C44H67O13Na
Molecular Weight:
827.0
MDL Number:
MFCD00210208
Packaging size:
10 UG
Product Description

Okadaic acid, sodium salt is a potent inhibitor of serine/threonine-specific protein phosphatases 1 and 2A (PP1 and PP2A) and of 2B at higher concentrations.It does not inhibit protein tyrosine phosphatases or kinases which have been tested.

Application Notes

Okadaic acid has been used to study various cellular processes such as the cell cycle and apoptosis including microtubule organization and tau hosphorylation. This phosphatase inhibitor has also played a role in the study of nitric oxide metabolism and calcium signaling. In addition, okadaic acid has been shown to activate transcription of the Cox-2 gene, disrupt golgi, arrest transport in the rough endoplasmic reticulum, and affect neurotransmitter release.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Inhibitor of type 1 and 2A protein phosphatases | Tumor promotor

Specifications
SKU 0215897410
Alternate Names OA; 9,10-deepithio-9,10-didehydroacanthifolicin
Application Notes Okadaic acid has been used to study various cellular processes such as the cell cycle and apoptosis including microtubule organization and tau hosphorylation. This phosphatase inhibitor has also played a role in the study of nitric oxide metabolism and calcium signaling. In addition, okadaic acid has been shown to activate transcription of the Cox-2 gene, disrupt golgi, arrest transport in the rough endoplasmic reticulum, and affect neurotransmitter release.
Base Catalog Number 15897410
Biochemical Physiological Actions Dinoflagellate toxin and an ionophore-like polyether derivative of a 38 carbon, fatty acid. Readily enters cells. Inhibitor of type 1 and type 2A protein phosphatases.
CAS # 78111-17-8
Hazard Statements H301-H311-H315-H331
Molecular Formula C44H67O13Na
Molecular Weight 827.0
Pack Size 10 UG
Preparation Method Preparation: Isolated from cultured Prorocentrum concavum by preparative flash, medium pressure and high performance liquid chromatography. Salf form generated in aqueous sodium hydroxide methanol solution.
Purity ≥98%
RTECS Number AA8227800
Safety Symbol GHS06
Solubility Soluble in water, ethanol or DMSO at 0.1 mg/mL. Soluble in acetonitrile at 1 mg/mL. Soluble in methanol and acetone. Soluble in ethyl acetate(250 µg/mL, 0.1% HOAc in CH<sub>3</sub>CN:H<sub>2</sub>O (1:1)).
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Datasheets

Datasheets
English (United States)

Certificates of Analysis

Certificates of Analysis
English (United States)