Leupeptin is a Inhibitor for trypsin, plasmin, papain, and cathepsin B.
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|Application Notes||Leupeptin is a Inhibitor for trypsin, plasmin, papain, and cathepsin B.|
|Base Catalog Number||151553|
|Biochemical Physiological Actions||Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)|
|Molecular Formula||C20H38N6O4 • 1/2H2SO4|
|Molecular Weight||951.196 g/mol|
|Personal Protective Equipment||Eyeshields, Gloves, respirator filter|
|Typical Working Concentration||Effective concentration 10-100 μM.|