Ketoconazole, ≥98%

Ketoconazole, ≥98%

Synonyms cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1M-idazol-1-ylmethyl)-1,3-dioxolan-4-yl) methoxy) phenyl)-piperazine; Fungarest; Fungoral; Ketoconazol; Ketoderm; Ketoisdin; KW-1414; Nizoral; R 41400; (±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine

CAS Number: 65277-42-1 Molecular Formula: C26H28N4O4Cl2 Molecular Weight: 531.434 g/mol

EC Number: 265-667-4 MDL Number: MFCD00058579

SKU 02159158-CF
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Description

Product Description

Ketoconazole

Application Notes

Ketoconazole is a broad spectrum antifungal agent used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is a CYP3A4 inhibitor. It is used to identify p-glycoprotein/CYP3A-limited bioavailability in the monkey model, to study interleukin 1 mediated antitumor effects, and drug interactions in vivo.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotics | Antifungal | Enzyme

Specifications
SKU 02159158-CF
Alternate Names cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-1M-idazol-1-ylmethyl)-1,3-dioxolan-4-yl) methoxy) phenyl)-piperazine; Fungarest; Fungoral; Ketoconazol; Ketoderm; Ketoisdin; KW-1414; Nizoral; R 41400; (±)-cis-1-Acetyl-4-(4-[(2-[2,4-dichlorophenyl]-2-[1H-imidazol-1-ylmethyl]-1,3-dioxolan-4-yl)-methoxy]phenyl)piperazine
Application Notes Ketoconazole is a broad spectrum antifungal agent used to treat candidiasis, chronic mucocutaneous candidiasis, oral thrush, candiduria, blastomycosis, coccidioidomycosis, histoplasmosis, chromomycosis, and paracoccidioidomycosis. It is a CYP3A4 inhibitor. It is used to identify p-glycoprotein/CYP3A-limited bioavailability in the monkey model, to study interleukin 1 mediated antitumor effects, and drug interactions in vivo.
Base Catalog Number 159158
Biochemical Physiological Actions Ketoconazole as an Antifungal agent, interacts with 14-α demethylase, a cytochrome P-450 enzyme that is necessary for the conversion of lanosterol to ergosterol. This interaction inhibits ergosterol synthesis and results in increased fungal cellular permeability. Other possible mechanisms of action are the inhibition of endogenous respiration, interaction with membrane phospholipids, inhibition of yeast transformation to mycelial forms, inhibition of purine uptake, and impairment of triglyceride and/or phospholipid biosynthesis. Ketoconazole inhibits the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone .
CAS # 65277-42-1
EC Number 265-667-4
Format Powder
Hazard Statements H301-H360F-H373-H410
Melting Point 146
Molecular Formula C26H28N4O4Cl2
Molecular Weight 531.434 g/mol
Personal Protective Equipment Eyeshields, Faceshields, Respirator cartridges
Purity ≥98%
RTECS Number TK7912300
Safety Symbol GHS06, GHS08, GHS09
Solubility <h5 class="minor-section-title">Water Solubility</h5>0.0866 mg/L
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 6.41X10-14 mm Hg at 25 deg C (est)