Furazolidone

Furazolidone

Synonyms 3-[[(5-Nitro-2-furanyl)methylene]-amino]-2-oxazolidinone; 3-(5-nitrofurfurylideneamino)-2-oxazolidinone; N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone; Furovag; Furoxane; Medaron; Topazone

CAS Number: 67-45-8 Molecular Formula: C8H7N3O5 Molecular Weight: 225.16 g/mol

Beilstein Registry Number: 8317414 EC Number: 200-653-3 MDL Number: MFCD00010550

SKU 02193465-CF
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Description

Product Description

Furazolidone

Application Notes

Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes. It also used as a DNA interstrand cross-linking agent.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibacterial

Specifications
SKU 02193465-CF
Alternate Names 3-[[(5-Nitro-2-furanyl)methylene]-amino]-2-oxazolidinone; 3-(5-nitrofurfurylideneamino)-2-oxazolidinone; N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone; Furovag; Furoxane; Medaron; Topazone
Application Notes Furazolidone is a nitrofuran derivative with antiprotozoal and antibacterial activity. Furazolidone binds bacterial DNA, which leads to the gradual inhibition of monoamine oxidase. It is used to treat anorexia and antagonism of thiamin utilization in poultry. Furazolidone increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes. It also used as a DNA interstrand cross-linking agent.
Base Catalog Number 193465
Beilstein Registry Number 8317414
Biochemical Physiological Actions Furazolidone and its generated free radicals, may bind to DNA and induce cross-links. Bacterial DNA is particularly susceptible to this drug, which results in high levels of mutations (transitions and transversions) in the bacterial chromosome. Its mechanism of action minimizes the development of resistant organisms. Furazolidone is a monoamine oxidase (MAO) inhibitor. It increases thapsigargin-sensitive Ca2+-ATPase in chick cardiac myocytes.
CAS # 67-45-8
EC Number 200-653-3
Format Powder
Hazard Statements H361
Melting Point 254-256
Molecular Formula C8H7N3O5
Molecular Weight 225.16 g/mol
Personal Protective Equipment Eyeshields, full-face particle respirator, Gloves, respirator filter,respirator cartridges
RTECS Number RQ3675000
Safety Symbol GHS08
Solubility Water Solubility40 mg/L (at 25 °C)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.