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Fibrinogen, fraction I, clottable protein: >80%, protein content: >70%

Fibrinogen, fraction I, clottable protein: >80%, protein content: >70%

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Fibrinogen

SKU: 02154165-CF

Synonyms
Factor I
CAS Number:
9001-32-5
Molecular Weight:
182.172 g/mol
EC Number:
232-598-6
MDL Number:
MFCD00163624
Product Description

Fibrinogen

Application Notes

Fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP).

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Clotting Factor

Specifications
SKU 02154165-CF
Alternate Names Factor I
Application Notes Fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP).
Base Catalog Number 154165
Biochemical Physiological Actions Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyzes fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.
CAS # 9001-32-5
EC Number 232-598-6
Format Powder
Molecular Weight 182.172 g/mol
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Protein or Enzyme Type Plasma & Blood Proteins
Purity Clottable Protein: >80%; Protein Content: >70%
Source Bovine
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
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