Etoposide

Etoposide

Synonyms EPA; Demethyl-epiodophyllotoxin ethylidene glucoside; Vepesid; EPEG; VP-16; VP-16213; NK 171; NSC-141540; 4'-Demethylepipodophyllotoxin; 9-(4,6-O-Ethylidene-b-D-Glucopyranoside)

CAS Number: 33419-42-0 Molecular Formula: C29H32O13 Molecular Weight: 588.562 g/mol

EC Number: 251-509-1 MDL Number: MFCD00869325

SKU 02193918-CF
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Description

Product Description

Etoposide

Application Notes

Etoposide inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53−/−) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Topoisomerase inhibitor

Specifications
SKU 02193918-CF
Alternate Names EPA; Demethyl-epiodophyllotoxin ethylidene glucoside; Vepesid; EPEG; VP-16; VP-16213; NK 171; NSC-141540; 4'-Demethylepipodophyllotoxin; 9-(4,6-O-Ethylidene-b-D-Glucopyranoside)
Application Notes Etoposide inhibits DNA synthesis and is very active against cells in the late S and G2 phases of the cell cycle. Etoposide was reported to be used to serum starve Saos-2 M5(p53−/−) cells which were transfected by electroporation with indicated expression plasmids for flag-E2F1 and myc-EBNA3C for selection of colony forming units, thus studying the blocking effect of EBV Nuclear Antigen 3C on E2F1 Mediated Apoptosis Induced by the DNA Damage Response.
Base Catalog Number 193918
Biochemical Physiological Actions Etoposide is an antitumor agent that complexes with topoisomerase II and DNA to enhance double-strand and single-strand cleavage of DNA and reversibly inhibit religation. Blocks the cell cycle in in S-phase and G2-phase of the cell cycle; induces apoptosis in normal and tumor cell lines; inhibits synthesis of the oncoprotein Mdm2 and induces apoptosis in tumor lines that overexpress Mdm2.
CAS # 33419-42-0
EC Number 251-509-1
Format Powder
Hazard Statements H302-H350
Melting Point 236-251 °C
Molecular Formula C29H32O13
Molecular Weight 588.562 g/mol
Personal Protective Equipment Eyeshields, Full-face particle respirator, Gloves, Respirator cartridge, Respirator filter
pKa 9.8 (Lit.)
RTECS Number KC0190000
Safety Symbol GHS07, GHS08
Solubility <h5 class="minor-section-title">Water Solubility</h5>Sparingly soluble
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance λmax (methanol)
Vapor Pressure 5.4X10-23 mm Hg at 25 deg C /Estimated/