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Endothelin 1, 250 μg

Endothelin 1, 250 μg

CN¥0.00
Endothelin 1

SKU: 02153092.2

Synonyms
Cys-Ser-Cys-Ser-Ser-Leu-Met- Asp-Lys-Glu-Cys-Val-Tyr-Phe- Cys-His-Leu-Asp-Ile-Ile-Trp; ET-1
CAS Number:
117399-94-7
Molecular Formula:
C109H159N25O32S5
Molecular Weight:
2491.914 g/mol
MDL Number:
MFCD00133305
Packaging size:
250 μg
Product Description

Endothelin 1

Application Notes

Endothelin 1 has been used for coating wells in polystryene ELISA plates. Endothelin-1 (ET-1) has been used to study the production and detection of H2O2 and production of NO in the presence of ET-1, for studying the effects of ET-1 on the eNOS/inducible NOS (iNOS)/caveolin-1 expression, NO production, isoform specific PKC translocation, and PKC activity in human saphenous vein endothelial cells (HSVECs).

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Coating wells in polystryene ELISA plates

Specifications
SKU 02153092.2
Alternate Names Cys-Ser-Cys-Ser-Ser-Leu-Met- Asp-Lys-Glu-Cys-Val-Tyr-Phe- Cys-His-Leu-Asp-Ile-Ile-Trp; ET-1
Application Notes Endothelin 1 has been used for coating wells in polystryene ELISA plates. Endothelin-1 (ET-1) has been used to study the production and detection of H2O2 and production of NO in the presence of ET-1, for studying the effects of ET-1 on the eNOS/inducible NOS (iNOS)/caveolin-1 expression, NO production, isoform specific PKC translocation, and PKC activity in human saphenous vein endothelial cells (HSVECs).
Base Catalog Number 153092.2
Biochemical Physiological Actions Endothelin-1 (ET-1) is a vasoconstrictor, which is increased in plasma and explants of patients with uterine leiomyomas. Thus, uterine fibroids are linked to increased ET-1 levels and hypertension, which is worsened by hypoxic condtions. ET-1 RNAi and Endostar are capable of preventing the progression and invasiveness of PC-3 (prostate cancer) cells. The plasma levels of this peptide are increased in patients with atrial septal defect (ASD), and these levels might help in diagnosis of closure defects. The plasma level of ET-1 is also higher in patients with end-stage renal disease (ESRD), and this is linked to gradual worsening of pulmonary function tests.Potent agonist for ETA and ETB endothelin receptors. Induces the production of hypoxia-inducible factor 1a, and, thus, the production of VEGF.
CAS # 117399-94-7
Format Powder
Molecular Formula C109H159N25O32S5
Molecular Weight 2491.914 g/mol
Pack Size 250 μg
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
RTECS Number KE9446500
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Documents

Certificates of Analysis

Certificates of Analysis
English (United States)

Datasheets

Datasheets
English (United States)