Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is used to inhibit matrix metalloproteinases and has been used to inhibit the inflammatory response of Lyme Disease.
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|Alternate Names||Biocamycin; Doxigalumicina; Doxycycline hyclate; Doxy-II; Midoxin; Novadox; Retens; Tetradox; Vibradox; Hydramycin; 2-Naphthacenecarboxamide, 4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, hydrochloride|
|Application Notes||Doxycycline hyclate is a synthetic oxytetracycline derivative. It has been used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and to eliminate Ixodes scapularis ticks. It is used to inhibit matrix metalloproteinases and has been used to inhibit the inflammatory response of Lyme Disease.|
|Base Catalog Number||195044|
|Beilstein Registry Number||5702728|
|Biochemical Physiological Actions||Derivative of oxytetracycline. A broad spectrum inhibitor used to inhibit matrix metallo-proteinases (MMP) such as type 1 collagenase in studies on wound healing and tissue remodeling.Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo. Doxycycline is frequently used to treat Lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease acne, rosacea, and rickettsial infections and prophylaxis of anthrax (caused by Bacillus anthracis). It is also effective against Yersinia pestis. Treatment with doxycycline inhibits collagen synthesis.|
|Molecular Formula||C22H24N2O8 • HCl|
|Molecular Weight||480.898 g/mol|
|Personal Protective Equipment||dust mask , Eyeshields, Gloves|
|Preparation Method||P261-P305 + P351 + P338|
|Source||Soluble in water (10 mg/mL - clear; yellowish to yellowish-green solution) and DMSO: soluble (50 mg/mL).|
|Unit Definition||It is typically used at a concentration of 20 ug/mL and is stable in media at 37 °C for approximately 5 days.|