The 17αOHP Coated Tube RIA Kit is intended for the measurement of 17α-hydroxyprogesterone in unextracted serum or plasma of adults and children. The steroid 17α-hydroxyprogesterone (17αOHP) is produced by both the adrenal cortex and gonads. Even though 17αOHP has relatively little progestational activity, it is of intense clinical interest because it is the immediate precursor to 11-desoxycortisol (Cpd-S). Because Cpd-S is produced by 21-hydroxylation of 17αOHP, measurement of 17αOHP is a useful indirect indicator of 21-hydroxylase activity. In congenital 21-hydroxylase deficiency, the most common variety of congenital adrenal hyperplasia (CAH), 17αOHP is secreted in abundant excess. It is moderately elevated in the 11-b-hydroxylase deficiency as well. Measurement of 17αOHP is therefore valuable in the initial diagnosis of CAH.
FDA cleared for In Vitro Diagnostic (IVD) use in the United States. CE Marked for IVD use outside the United States.
|Analyte / Target||17OHP (17 alpha hydroxyprogesterone)|
|Base Catalog Number||271101|
|Sample Type||Plasma, Serum|
|Sample Volume||25 uL|
|Usage Statement||FDA cleared for In Vitro Diagnostic (IVD) use in the United States. CE Marked for IVD use outside the United States.|