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Dacarbazine , 250 mg

Dacarbazine , 250 mg

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SKU: 0215751983

Synonyms
5-[3,3-Dimethyl-1-triazenyl]imidazole-4-carboxamide; DTIC
CAS Number:
4342-03-4
Molecular Formula:
C6H10N6O
Molecular Weight:
182.2
EC Number:
224-396-1
MDL Number:
MFCD00057167
Packaging size:
250 mg
Specifications
SKU 0215751983
Alternate Names 5-[3,3-Dimethyl-1-triazenyl]imidazole-4-carboxamide; DTIC
Application Notes Dacarbazine is a triazine antineoplastic agent that is used for DNA methylation via formation of methyl adducts. It is used to treat metastatic malignant melanomas and Hodgkin′s when used in combination with other antineoplastic agents. It is used to induce apoptosis in human cells. It has been used to induce hepatotoxicity in mice.
Base Catalog Number 15751983
Biochemical Physiological Actions Dacarbazine has significant activity against melanomas. It is a synthetic analog of naturally occurring purine precursor 5-amino-1H-imidazole-4-carboxamide (AIC). Dacarbazine appears to exert cytotoxic effects by acting as an alkylating agent, by inhibiting DNA synthesis as a purine analog, and by inducing apoptosis. Dacarbazine is not cell cycle-phase specific.
CAS # 4342-03-4
EC Number 224-396-1
Hazard Statements H312-H315-H319-H332-H335-H350
Melting Point 202 °C (Lit.)
Molecular Formula C6H10N6O
Molecular Weight 182.2
Pack Size 250 mg
Personal Protective Equipment Eyeshields, full-face particle respirator, Gloves, respirator filter, respirator cartridges
RTECS Number NI3950000
Safety Symbol GHS07, GHS08
Solubility Soluble in 1 M HCl (40 mg/mL - clear to turbid, faint yellow solution).
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
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Certificates of Analysis
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Certificates of Analysis
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