Clozapine

Clozapine

Synonyms HF1854; Clozaril; Clorazil; Leponex; Lepotex; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; Iprox; W-801

CAS Number: 5786-21-0 Molecular Formula: C18H19N4Cl Molecular Weight: 326.828 g/mol

EC Number: 227-313-7 MDL Number: MFCD00153785

SKU 02159760-CF
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Description

Product Description

Clozapine

Application Notes

Clozapine has dopamine receptor blocking activity, α-adrenergic blocking, antimuscarinic, antihistamine, and antiserotonergic properties. The role of clozapine in reversing the inhibitory effect of dopamine on sodium and water transport in the rat cortical collecting duct has been reviewed. Clozapine has been used to probe the role of the calcium/calmodulin-dependent kinase II in NMDA-induced inward currents and electrically evoked excitatory postsynaptic currents in mouse brain sections, cultured mouse cells, and transgenic mice.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Blocking of dopamine receptor

Specifications
SKU 02159760-CF
Alternate Names HF1854; Clozaril; Clorazil; Leponex; Lepotex; 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo (b,e)(1,4)diazepine; Iprox; W-801
Application Notes Clozapine has dopamine receptor blocking activity, α-adrenergic blocking, antimuscarinic, antihistamine, and antiserotonergic properties. The role of clozapine in reversing the inhibitory effect of dopamine on sodium and water transport in the rat cortical collecting duct has been reviewed. Clozapine has been used to probe the role of the calcium/calmodulin-dependent kinase II in NMDA-induced inward currents and electrically evoked excitatory postsynaptic currents in mouse brain sections, cultured mouse cells, and transgenic mice.
Base Catalog Number 159760
Biochemical Physiological Actions A typical antipsychotic compound. Selective antagonist for D4- dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors.
CAS # 5786-21-0
EC Number 227-313-7
Extinction Coefficient Ethanol: 27.4 (215 nm), 25.8 (230 nm), 16.8 (261 nm), 10.5 (297 nm) (Lit.)
Format Powder
Hazard Statements H301-H341-H361
Melting Point 183-184 °C
Molecular Formula C18H19N4Cl
Molecular Weight 326.828 g/mol
RTECS Number HP1750000
Safety Symbol GHS06, GHS08
Solubility Water Solubility11.8 mg/L
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 1.12X10-8 mm Hg at 25 deg C (est)