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Clotrimazole, 100 g

Clotrimazole, 100 g

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Clotrimazole

SKU: 0219894480

Synonyms
1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole; 1-(o-Chloro-α,α-diphenylbenzyl)imidazole; diphenyl-(2-chlorophenyl)-1-imidazolylmethane
CAS Number:
23593-75-1
Molecular Formula:
C22H17ClN2
Molecular Weight:
344.842 g/mol
EC Number:
245-764-8
MDL Number:
MFCD00057220
Packaging size:
100 g
Product Description

Clotrimazole

Application Notes

Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antifungal azole

Specifications
SKU 0219894480
Alternate Names 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole; 1-(o-Chloro-α,α-diphenylbenzyl)imidazole; diphenyl-(2-chlorophenyl)-1-imidazolylmethane
Application Notes Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole.
Base Catalog Number 19894480
Biochemical Physiological Actions Mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
CAS # 23593-75-1
EC Number 245-764-8
Format Powder
Hazard Statements H302-H315-H319
Melting Point 154-156
Molecular Formula C22H17ClN2
Molecular Weight 344.842 g/mol
Pack Size 100 g
Personal Protective Equipment Dust mask, Eyeshields, Gloves
pH WEAK BASE
RTECS Number NI4377000
Safety Symbol GHS07
Solubility 3.7 [ug/mL]
Typical Working Concentration A concentration of 3μg/mL of clotrimazole is generally effective for inhibiting many fungal species that are sensitive to clotrimazole.
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance λmax: 261 nm (Lit.)