Clotrimazole, 100 g

Clotrimazole, 100 g

Synonyms 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole; 1-(o-Chloro-α,α-diphenylbenzyl)imidazole; diphenyl-(2-chlorophenyl)-1-imidazolylmethane

CAS Number: 23593-75-1 Molecular Formula: C22H17ClN2 Molecular Weight: 344.842 g/mol

EC Number: 245-764-8 MDL Number: MFCD00057220

Packaging size: 100 g

SKU 0219894480
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Description

Product Description

Clotrimazole

Application Notes

Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antifungal azole

Specifications
SKU 0219894480
Alternate Names 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole; 1-(o-Chlorotrityl)imidazole; 1-(o-Chloro-α,α-diphenylbenzyl)imidazole; diphenyl-(2-chlorophenyl)-1-imidazolylmethane
Application Notes Clotrimazole is used as an antifungal azole. Clotrimazole has been utilized in vitro on cultured human prostate cancer cells to counteract the proliferative effects of 1-ethyl-2-benzimidazolinone and riluzole.
Base Catalog Number 19894480
Biochemical Physiological Actions Mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
CAS # 23593-75-1
EC Number 245-764-8
Format Powder
Hazard Statements H302-H315-H319
Melting Point 154-156
Molecular Formula C22H17ClN2
Molecular Weight 344.842 g/mol
Pack Size 100 g
Personal Protective Equipment Dust mask, Eyeshields, Gloves
pH WEAK BASE
RTECS Number NI4377000
Safety Symbol GHS07
Solubility 3.7 [ug/mL]
Typical Working Concentration A concentration of 3μg/mL of clotrimazole is generally effective for inhibiting many fungal species that are sensitive to clotrimazole.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance λmax: 261 nm (Lit.)