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CHAPSO, ≥98%

CHAPSO, ≥98%

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CHAPSO is the hydroxy analog of CHAPS; a nondenaturing zwitterionic detergent for solubilizing proteins, especially integral membrane proteins while maintaining the functional capability of the protein of interest. It has a more polar head group than CHAPS, giving it a greater solubility. CHAPSO has a high CMC (8 mM) and does not denature membrane-bound proteins. It can solubilize the opiate receptor in a state exhibiting reversible binding of opiates.

SKU: 02190320-CF

Synonyms
3-[(3-Cholamidopropyl)-dimethylammonio]-2-hydroxy-1-propane sulfonate
CAS Number:
82473-24-3
Molecular Formula:
C32H58N2O8S
Molecular Weight:
630.9
Beilstein Registry Number:
5842642
MDL Number:
MFCD00081079
Product Description

CHAPSO is the hydroxy analog of CHAPS; a nondenaturing zwitterionic detergent for solubilizing proteins, especially integral membrane proteins while maintaining the functional capability of the protein of interest. It has a more polar head group than CHAPS, giving it a greater solubility. CHAPSO has a high CMC (8 mM) and does not denature membrane-bound proteins. It can solubilize the opiate receptor in a state exhibiting reversible binding of opiates.

Application Notes

A nondenaturing zwitterionic detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Solubilization of integral membrane proteins

Specifications
SKU 02190320-CF
Aggregation Number 11
Alternate Names 3-[(3-Cholamidopropyl)-dimethylammonio]-2-hydroxy-1-propane sulfonate
Application Notes A nondenaturing zwitterionic detergent with characteristics similar to CHAPS, although it is more soluble due to a more polar head group. Useful for the solubilization of integral membrane proteins.
Base Catalog Number 190320
Beilstein Registry Number 5842642
CAS # 82473-24-3
Critical Micelle Concentration 8 mM
Hazard Statements H315-H319-H335
Melting Point 184-186 °C (Lit.)
Molecular Formula C32H58N2O8S
Molecular Weight 630.9
Personal Protective Equipment Dust mask, Eyeshields, Gloves
pH 5.0 - 9.0 (10% aq soln)
Purity ≥98%
Safety Symbol GHS07
Solubility Soluble in water (100 mg/mL - clear, colorless to slight yellowish solution), methanol (40 mg/mL- clear, colorless solution).
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance OD350 nm (1%aq soln): <0.04
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