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Gly-Phe-7-Amino-4-trifluoromethylcoumarin

Gly-Phe-7-Amino-4-trifluoromethylcoumarin

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Key features and details

Gly-Phe-7-Amino-4-Trifluoromethylcoumarin

SKU: 03AFC033-CF

Synonyms
Gly-Phe-AFC; GF-AFC
CAS Number:
Not yet assigned
Molecular Formula:
C21H18F3N3O4
Product Description

Gly-Phe-7-Amino-4-Trifluoromethylcoumarin

Application Notes

Gly-Phe-AFC is a fluorogenic, cell-permeant peptide substrate use to measure number of live cells in cytotoxic assay. It enters intact cells where it is cleaved to generate a fluorescent signal proportional to the number of living cells. This live-cell protease activity marker becomes inactive upon loss of membrane integrity and leakage into the surrounding culture medium. It is also used as substrate for measuring Dipeptidyl peptidase1 (DPP1) activity. DPP1 is a lysosomal cysteinyl protease of the papain family involved in the intracellular degradation of proteins.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Substrate in Cytotoxicity Assay | Substrate in measurement of Dipeptidyl peptidase1 activity

Specifications
SKU 03AFC033-CF
Alternate Names Gly-Phe-AFC; GF-AFC
Application Notes Gly-Phe-AFC is a fluorogenic, cell-permeant peptide substrate use to measure number of live cells in cytotoxic assay. It enters intact cells where it is cleaved to generate a fluorescent signal proportional to the number of living cells. This live-cell protease activity marker becomes inactive upon loss of membrane integrity and leakage into the surrounding culture medium. It is also used as substrate for measuring Dipeptidyl peptidase1 (DPP1) activity. DPP1 is a lysosomal cysteinyl protease of the papain family involved in the intracellular degradation of proteins.
Base Catalog Number AFC033
CAS # Not yet assigned
Format Powder
Molecular Formula C21H18F3N3O4
Protein or Enzyme Type Activators, Inhibitors & Substrates
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Citations
Documents

Certificate of Analysis

Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis
Certificate of Analysis

Datasheet

Datasheet

Material Safety Datasheet

Material Safety Datasheet
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