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(-)-Epigallocatechin gallate

(-)-Epigallocatechin gallate

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Key features and details

(-)-Epigallocatechin Gallate

SKU: 02199165-CF

Synonyms
(2R,3R)-2-(3,4,5-Trihydroxyphenyl)- 3,4-dihydro- 1(2H)- benzopyran-3,5,7- triol 3-(3,4,5-trihydroxybenzoate); (-)-Epigallocatechin 3-O-gallate; EGCG; (−)-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate; (−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate
CAS Number:
989-51-5
Molecular Formula:
C22H18O11
Molecular Weight:
458.375 g/mol
MDL Number:
MFCD00075940
Product Description

(-)-Epigallocatechin Gallate

Application Notes

(-)-Epigallocatechin Gallate inhibits cellular oxidation of low density lipoproteins. It also inhibits the peroxynitrite-induced formation of the oxidative injury markers 8-hydroxy-2-deoxy guanosine and 3-nitrotyrosine, apoptosis in human prostate cancer cells. Selectively inhibits activation of JNK/SAPK signaling pathway and suppresses proliferation of vascular smooth muscle cells. Shows growth inhibitory effects on tumor cells but not their normal counterparts. Inhibits telomerase. A fast-binding and reversible fatty acid synthase inhibitor. Inhibits PMA-induced skin thickening. Inhibits activation of interleukin-1α mRNA and protein expression. Inhibits nitric oxide synthase (iNOS) gene expression. At µM concentrations, it inhibits VEGF-induced tyrosine phosphorylation.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Inhibits cellular oxidation

Specifications
SKU 02199165-CF
Alternate Names (2R,3R)-2-(3,4,5-Trihydroxyphenyl)- 3,4-dihydro- 1(2H)- benzopyran-3,5,7- triol 3-(3,4,5-trihydroxybenzoate); (-)-Epigallocatechin 3-O-gallate; EGCG; (−)-cis-3,3′,4′,5,5′,7-Hexahydroxy-flavane-3-gallate; (−)-cis-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate
Application Notes (-)-Epigallocatechin Gallate inhibits cellular oxidation of low density lipoproteins. It also inhibits the peroxynitrite-induced formation of the oxidative injury markers 8-hydroxy-2-deoxy guanosine and 3-nitrotyrosine, apoptosis in human prostate cancer cells. Selectively inhibits activation of JNK/SAPK signaling pathway and suppresses proliferation of vascular smooth muscle cells. Shows growth inhibitory effects on tumor cells but not their normal counterparts. Inhibits telomerase. A fast-binding and reversible fatty acid synthase inhibitor. Inhibits PMA-induced skin thickening. Inhibits activation of interleukin-1α mRNA and protein expression. Inhibits nitric oxide synthase (iNOS) gene expression. At µM concentrations, it inhibits VEGF-induced tyrosine phosphorylation.
Base Catalog Number 199165
Biochemical Physiological Actions Antioxidant polyphenol flavonoid that inhibits telomerase and DNA methyltransferase. EGCG blocks the activation of EGF receptors and HER-2 receptors. ECGG inhibits fatty acid synthase and glutamate dehydrogenase activity.
CAS # 989-51-5
Extinction Coefficient EM(275 nm) = 11,500 (ethanol)(Lit.)
Format Powder
Melting Point 140 - 142 °C
Molecular Formula C22H18O11
Molecular Weight 458.375 g/mol
Optical Rotation -185° ±2° (ethanol)(Lit.)
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
Purity ≥95%
RTECS Number KB5200000
Source Green tea; Folium Camelliae
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Citations
Documents

Certificates of Analysis

Certificates of Analysis
English (United States)