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Rifampin, phytopure™

Rifampin, phytopure™

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Key features and details

CAS Number: 13292-46-1

SKU: 02195490-CF

Synonyms
Rifamycin AMP; Rifampicin; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV; Rifampicin
CAS Number:
13292-46-1
Molecular Formula:
C43H58N4O12
Molecular Weight:
822.90
Beilstein Registry Number:
5723476
EC Number:
236-312-0
MDL Number:
MFCD00151389
Product Description

A bactericidal antibiotic drug of the rifamycin group. It specifically inhibits DNA-dependent bacterial RNA Polymerase. Mammalian RNA polymerase is not affected so it is useful in plant cell culture work. It is effective against mycobacteria. Also an inhibitor of chloroplast RNA polymerase and may be used to study chloroplast-level DNA transcription in plants.

Application Notes

Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotic | Inhibitor of transcription initiation | Antipruritic agent

Specifications
SKU 02195490-CF
Alternate Names Rifamycin AMP; Rifampicin; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV; Rifampicin
Application Notes Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.
Base Catalog Number 195490
Beilstein Registry Number 5723476
Biochemical Physiological Actions Mode of Action: Inhibits initiation of RNA synthesis by binding to β-subunit of RNA polymerase. It Inhibits the assembly of DNA and protein into mature virus particles.
CAS # 13292-46-1
EC Number 236-312-0
Extinction Coefficient EmM (max absorbance, phosphate buffer,pH 7.38): 33.20 (237 nm); 32.10 (255 nm); 27.00 (334 nm);15.40 (475 nm)(Lit.)
Format Powder
Hazard Statements H302-H315-H319-H335
Isoelectric Point 4.8(in water)(Lit.)
Melting Point 183 °C
Molecular Formula C43H58N4O12
Molecular Weight 822.90
Optical Rotation [α]D25°=+10.6° (c=0.5% in CDCl3)(Lit.)
Personal Protective Equipment Dust mask, Eyeshields, Gloves
pKa pKa (in water):1.7 (4-hydroxyl group), 7.9 (4-piperazine nitrogen); in methylcellosolve-water (4:1): 3.6 (4-hydroxyl group), 6.7 (3-piperazine nitrogen)(Lit.)
RTECS Number VJ7000000
Safety Symbol GHS07
Solubility <h5 class="minor-section-title">Water Solubility</h5>1400 mg/L (at 25 °C)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
UV Visible Absorbance λ max (methanol): 237 - 239, 334 - 338, 475 - 479 nm
Vapor Pressure 3.1X10-34 mm Hg at 25 deg C /Estimated/
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