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Muscimol

Muscimol

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Key features and details

Muscimol

SKU: 02195336-CF

Synonyms
3-Hydroxy-5-aminomethylisoxazole; 5-Aminomethyl-3-hydroxy-isoxazole; 5-Aminomethyl-3-isoxazolol
CAS Number:
2763-96-4
Molecular Formula:
C4H6N2O2
Molecular Weight:
114.104 g/mol
Beilstein Registry Number:
1618960
EC Number:
220-430-4
MDL Number:
MFCD00057894
Product Description

Muscimol

Application Notes

Muscimol has been widely used to reversibly inactivate localized groups of neurons. It can also be used, in place of radioactive reagents and methods, to map the distribution of muscimol in the nervous system, as well as to detect the presence of GABAA receptors on cell surfaces. Muscimol was also reported to cause change in the water intake of the mice. In cultured rat oligodendrocytes, muscimol has been shown to lead to a reduction in intracellular Cl-content, cell shrinkage, and stimulated Na-K-2Cl cotransporter isoform 1 (NKCC1) activity. Muscimol (50 mM) has been utilized to probe the role of the p42/44 mitogenactivated protein kinase (MAPK) cascade in the development of cultured rat hypothalamic neurons.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

GABA-agonist

Specifications
SKU 02195336-CF
Alternate Names 3-Hydroxy-5-aminomethylisoxazole; 5-Aminomethyl-3-hydroxy-isoxazole; 5-Aminomethyl-3-isoxazolol
Application Notes Muscimol has been widely used to reversibly inactivate localized groups of neurons. It can also be used, in place of radioactive reagents and methods, to map the distribution of muscimol in the nervous system, as well as to detect the presence of GABAA receptors on cell surfaces. Muscimol was also reported to cause change in the water intake of the mice. In cultured rat oligodendrocytes, muscimol has been shown to lead to a reduction in intracellular Cl-content, cell shrinkage, and stimulated Na-K-2Cl cotransporter isoform 1 (NKCC1) activity. Muscimol (50 mM) has been utilized to probe the role of the p42/44 mitogenactivated protein kinase (MAPK) cascade in the development of cultured rat hypothalamic neurons.
Base Catalog Number 195336
Beilstein Registry Number 1618960
Biochemical Physiological Actions GABAA receptor agonist.
CAS # 2763-96-4
EC Number 220-430-4
Format Powder
Hazard Statements H300
Melting Point 347° F decomposes (EPA, 1998)
Molecular Formula C4H6N2O2
Molecular Weight 114.104 g/mol
Personal Protective Equipment Eyeshields, Faceshields, Gloves, Respirator cartridges
RTECS Number NY3325000
Safety Symbol GHS06
Solubility In <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/water">water</a>, 5.67X10+5 mg/L (est)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 2.94X10-4 mm Hg at 25 deg C (est)
Citations
Documents

Datasheet

Datasheet