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Paclitaxel

Paclitaxel

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Key features and details

Paclitaxel

SKU: 02193532-CF

Synonyms
Taxol® (Bristol-Myers Squibb); Taxol A; NSC 125973
CAS Number:
33069-62-4
Molecular Formula:
C47H51NO14
Molecular Weight:
853.918 g/mol
Beilstein Registry Number:
1420457
MDL Number:
MFCD00869953
Product Description

Paclitaxel

Application Notes

Paclitaxel has been used as a component of the dechorionation buffer for Gryllus bimaculatus eggs. Paclitaxel has also been used for studying its effect on the movement of all-trans retinoic acid (ATRA) differentiated NB4 cells.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Anti-neoplastic agent | Anti-mitotic drug | Antitumor agent | Antileukemic agent

Specifications
SKU 02193532-CF
Alternate Names Taxol® (Bristol-Myers Squibb); Taxol A; NSC 125973
Application Notes Paclitaxel has been used as a component of the dechorionation buffer for Gryllus bimaculatus eggs. Paclitaxel has also been used for studying its effect on the movement of all-trans retinoic acid (ATRA) differentiated NB4 cells.
Base Catalog Number 193532
Beilstein Registry Number 1420457
Biochemical Physiological Actions Antitumor and antileukemic agent which lowers the critical concentration for tubulin polymerization and reversibly binds to tubulin prohibiting depolymerization; binds to the N-terminal region of beta-tubulin and promotes the formation of highly stable microtubles that resist depolymerization, thus preventing normal cell division and arresting the cell cycle at the G2-M phase. The microtubule damage induces apoptosis through a JNK-dependent pathway in the early phase followed by a JNK-independent pathway, perhaps related to the activation of protein kinase A or of Raf-1 kinase, that results in phosphorylation of Bcl-2.
CAS # 33069-62-4
Format Powder
Hazard Statements H315-H317-H318-H334-H335-H341-H361-H371
Melting Point 415 to 421° F (NTP, 1992)
Molecular Formula C47H51NO14
Molecular Weight 853.918 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
Purity ≥98%
RTECS Number DA8340700
Safety Symbol GHS05, GHS07, GHS08
Solubility <h5 class="minor-section-title">Water Solubility</h5>Insoluble
Source Taxus brevifolia(Pacific Yew Bark)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Citations
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