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Indomethacin, ≥98%

Indomethacin, ≥98%

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Key features and details

Indomethacin

SKU: 02190217-CF

Synonyms
Indometacin; 1-[p-Chlorobenzoyl]-5-methoxy-2-methylindole-3-acetic acid; 1-(4-Chlorobenzoyl)-5- methoxy-2-methyl-1H-indole-3-acetic acid; 1-(p-Chlorobenzoyl)-5- methoxy-2-methyl-3- indolylacetic acid
CAS Number:
53-86-1
Molecular Formula:
C19H16ClNO4
Molecular Weight:
357.79 g/mol
Beilstein Registry Number:
497341
EC Number:
200-186-5
MDL Number:
MFCD00057095
Product Description

Indomethacin

Application Notes

Inhibitor of cyclooxygenase (prostaglandin H synthase 1 and 2). An anti-inflammatory (by blocking prostaglandin biosynthesis by inhibiting cyclooxygenase), antipyretic and analgesic agent. May help prevent the stimulation of tumor cell growth and the suppression of immune surveillance caused by cyclooxygenase's ability to convert arachidonic acid to pro-inflammatory substances such as prostaglandins. Indomethacin is metabolized by the liver and the metabolites excreted in the urine.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Antibiotics | Antitumor Agent

Specifications
SKU 02190217-CF
Alternate Names Indometacin; 1-[p-Chlorobenzoyl]-5-methoxy-2-methylindole-3-acetic acid; 1-(4-Chlorobenzoyl)-5- methoxy-2-methyl-1H-indole-3-acetic acid; 1-(p-Chlorobenzoyl)-5- methoxy-2-methyl-3- indolylacetic acid
Application Notes Inhibitor of cyclooxygenase (prostaglandin H synthase 1 and 2). An anti-inflammatory (by blocking prostaglandin biosynthesis by inhibiting cyclooxygenase), antipyretic and analgesic agent. May help prevent the stimulation of tumor cell growth and the suppression of immune surveillance caused by cyclooxygenase's ability to convert arachidonic acid to pro-inflammatory substances such as prostaglandins. Indomethacin is metabolized by the liver and the metabolites excreted in the urine.
Base Catalog Number 190217
Beilstein Registry Number 497341
Biochemical Physiological Actions Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.
CAS # 53-86-1
EC Number 200-186-5
Extinction Coefficient EmM (230 nm) = 20.8 (in ethanol), EmM (260 nm) = 16.2 (in ethanol), EmM (319 nm) = 6.29 (in ethanol),(Lit.)
Format Powder
Hazard Statements H300
Melting Point 311 or 323.6° F (NTP, 1992)
Molecular Formula C19H16ClNO4
Molecular Weight 357.79 g/mol
Personal Protective Equipment Eyeshields, Faceshields, full-face particle respirator, Gloves, Respirator cartridge,Respirator filter
pKa 4.5(Lit.)
Purity ≥98%
RTECS Number NL3500000
Safety Symbol GHS06
Solubility Water Solubility0.937 mg/L (at 25 °C)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 9.89X10-11 mm Hg at 25 deg C (est)
Citations
Documents

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