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Anisomycin

Anisomycin

Key features and details

Anisomycin

SKU: 02159881-CF

Synonyms
2-[p-Methoxybenzyl]-3,4- pyrrolidinediol 3-acetate; (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate; Flagecidin
CAS Number:
22862-76-6
Molecular Formula:
C14H19NO4
Molecular Weight:
265.309 g/mol
Beilstein Registry Number:
20705
EC Number:
245-269-7
MDL Number:
MFCD00077650
Product Description

Anisomycin

Application Notes

Anisomycin is an antiprotozoal agent. It inhibits protein synthesis. Activates a restricted subset of kinases currently only identified by p54 and MAP kinase. Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Inhibits protein synthesis | Activates a restricted subset of kinases | Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.

Specifications
SKU 02159881-CF
Alternate Names 2-[p-Methoxybenzyl]-3,4- pyrrolidinediol 3-acetate; (2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate; Flagecidin
Application Notes Anisomycin is an antiprotozoal agent. It inhibits protein synthesis. Activates a restricted subset of kinases currently only identified by p54 and MAP kinase. Study aid for cytoplasmic signals resulting in nuclear signaling and induction of c-fos and c-jun.
Base Catalog Number 159881
Beilstein Registry Number 20705
Biochemical Physiological Actions Acts by inhibiting peptidyl transferase activity in eukaryote ribosomes. Reported to induce apoptosis in a variety of cells including promyelocytic leukemia cells, Jurkat cells, ventricular myocytes, and colon adenocarcinoma cells. Initiates intracellular signals and immediate early gene induction. Selective signaling agonist. Potent Jun-NH2 terminal kinase (JNK) agonist. Activates mitogen-activated protein (MAP) kinases (JNK/SAPK and p38/RK).
CAS # 22862-76-6
EC Number 245-269-7
Format Powder
Hazard Statements H301
Molecular Formula C14H19NO4
Molecular Weight 265.309 g/mol
Optical Rotation [α]D23 = −30 ° (methanol) (Lit.)
Personal Protective Equipment Eyeshields, Faceshields, Gloves, respirator cartridges
Purity ≥97%
RTECS Number BZ9800000
Safety Symbol GHS06
Source Streptomyces griseolus
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Citations
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