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Brefeldin A

Brefeldin A

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Key features and details

Brefeldin A

SKU: 02159027-CF

Synonyms
(-4-Dihydroxy-2-[6-Hydroxy-1-Heptenyl]-4-Cyclopentane Crotonic Acid 8-Lactone; BFA; Ascotoxin; Cyanein; Decumbin
CAS Number:
20350-15-6
Molecular Formula:
C16H24O4
Molecular Weight:
280.364 g/mol
Beilstein Registry Number:
25191
MDL Number:
MFCD12913297
Product Description

Brefeldin A

Application Notes

Brefeldin A reversibly inhibits the intracellular translocation of proteins in eukaryotes, e.g., during transport of proteins to the cell surface for secretion or expression. It has been reported to block the response of cultured cells to cholera toxin. BFA inhibits protein synthesis in cultured cells and inhibits the transport of secretory and lysosomal proteins at concentrations of 1-10 µg/mL. In HepG2 cells, BFA induces two blocks in the secretory pathway; one at the level of the endoplasmic reticulum-Golgi juncture and the other in the trans-Golgi network. Brefeldin A is used in the studies of Brefeldin A-inhibited Guanine Nucleotide-exchange Protein, BIG2, Regulates the Constitutive Release of TNFR1 Exosome-like Vesicles.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Brefeldin A blocks protein transportation into post-Golgi compartments.

Specifications
SKU 02159027-CF
Alternate Names (-4-Dihydroxy-2-[6-Hydroxy-1-Heptenyl]-4-Cyclopentane Crotonic Acid 8-Lactone; BFA; Ascotoxin; Cyanein; Decumbin
Application Notes Brefeldin A reversibly inhibits the intracellular translocation of proteins in eukaryotes, e.g., during transport of proteins to the cell surface for secretion or expression. It has been reported to block the response of cultured cells to cholera toxin. BFA inhibits protein synthesis in cultured cells and inhibits the transport of secretory and lysosomal proteins at concentrations of 1-10 µg/mL. In HepG2 cells, BFA induces two blocks in the secretory pathway; one at the level of the endoplasmic reticulum-Golgi juncture and the other in the trans-Golgi network. Brefeldin A is used in the studies of Brefeldin A-inhibited Guanine Nucleotide-exchange Protein, BIG2, Regulates the Constitutive Release of TNFR1 Exosome-like Vesicles.
Base Catalog Number 159027
Beilstein Registry Number 25191
Biochemical Physiological Actions Brefeldin A (BFA) is a fungal metabolite which disrupts the structure and function of the Golgi apparatus. BFA is an activator of the sphingomyelin cycle. Brefeldin A-mediated apoptosis has been observed in human tumor cells.
CAS # 20350-15-6
Hazard Statements H301
Molecular Formula C16H24O4
Molecular Weight 280.364 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Faceshields, Gloves
Purity ≥98%
RTECS Number GY8410000
Safety Symbol GHS06
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
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