13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.
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Anti-inflammatory | Anti-tumor
|Application Notes||13-cis-Retinoic acid (RA) has anti-inflammatory and anti-tumor action.|
|Base Catalog Number||156518|
|Biochemical Physiological Actions||The action of 13-cis-Retinoic acid (RA) is mediated through RAR-β and RAR-α receptors. RA attenuates iNOS expression and activity in cytokine-stimulated murine mesangial cells. It induces mitochondrial membrane permeability transition, observed as swelling and as a decrease in membrane potential, and stimulates the release of cytochrome c implicating mechanisms through the apoptosis pathway. These activities are reversed by EGTA and cyclosporin A. RA also increases MMP-1 protein expression partially via increased transcription.|
|Melting Point||372 to 374Â° F (NTP, 1992)|
|Molecular Weight||300.442 g/mol|
|Personal Protective Equipment||Eyeshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter|
|Safety Symbol||GHS07, GHS08|
|Solubility||less than 1 mg/mL at 72Â° F (NTP, 1992)|
|UV Visible Absorbance||λ max (ethanol): 354 ± 3 nm|
|Vapor Pressure||1.0X10-7 mm Hg @ 25 deg C /Estimated/|