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Phorbol-12-myristate-13-acetate, >99%

Phorbol-12-myristate-13-acetate, >99%

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Key features and details

Phorbol-12-Myristate-13-Acetate

SKU: 02151864-CF

Synonyms
Phorbol Acetate Myristate; Phorbol Monoacetate Monomyristate; PMA; 12-O-Tetradecanoylphorbol 13-acetate; 4,9,12,13,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate; TPA
CAS Number:
16561-29-8
Molecular Formula:
C36H56O8
Molecular Weight:
616.836 g/mol
Beilstein Registry Number:
2407201
MDL Number:
MFCD00036736
Product Description

Phorbol-12-Myristate-13-Acetate

Application Notes

PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

Usage Statement

Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.

Key Applications

Very Potent tumor promoter

Specifications
SKU 02151864-CF
Alternate Names Phorbol Acetate Myristate; Phorbol Monoacetate Monomyristate; PMA; 12-O-Tetradecanoylphorbol 13-acetate; 4,9,12,13,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate; TPA
Application Notes PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Base Catalog Number 151864
Beilstein Registry Number 2407201
Biochemical Physiological Actions Potent tumor promoter; activates protein kinase C in vivo and in vitro.
CAS # 16561-29-8
Hazard Statements H315
Melting Point 162° F (NTP, 1992)
Molecular Formula C36H56O8
Molecular Weight 616.836 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Purity 99%
RTECS Number QH4377000
Safety Symbol GHS07
Solubility Practically insoluble (NTP, 1992)
Usage Statement Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Vapor Pressure 1.8X10-17 mm Hg at 25 deg C (est)
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