Cytochalasin D possesses antibiotic and antitumor activity. It also impairs maintenance of long term potentiation (LTP) of actin filaments. It is implicated in promoting conditions favorable for depolymerizing actin.
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Potent inhibitor of actin polymerization
|Alternate Names||Zygosporin A; 3-Benzyl-3,3-alpha, 4, 5, 6, 6-alpha, 9, 10, 12, 15-Decahydro-6, 12, 15-Trihydroxy-4, 10, 12-Trimethyl-5-Methylene-1H-Cycloundec(d)isoindole-1, 11(2H) Dione, 15-Acetate|
|Application Notes||Cytochalasin D possesses antibiotic and antitumor activity. It also impairs maintenance of long term potentiation (LTP) of actin filaments. It is implicated in promoting conditions favorable for depolymerizing actin.|
|Base Catalog Number||150771|
|Beilstein Registry Number||1632828|
|Biochemical Physiological Actions||Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.|
|Melting Point||491 to 500Â° F (decomposes) (NTP, 1992)|
|Molecular Weight||507.627 g/mol|
|Personal Protective Equipment||Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator filter, respirator cartridges|
|Safety Symbol||GHS06, GHS08|